CAF1
Gene Ontology Biological Process
- DNA repair [TAS]
- DNA replication-dependent nucleosome assembly [NAS]
- chromatin assembly [IDA, ISS]
- chromatin silencing [IPI]
- dendrite morphogenesis [IMP]
- eggshell chorion gene amplification [IC]
- histone acetylation [IDA, ISS]
- histone methylation [IDA]
- mitotic cytokinesis [IMP]
- muscle organ development [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IMP]
- neuron development [IMP]
- neuron projection morphogenesis [IMP]
- nucleosome assembly [IDA, NAS]
- nucleosome mobilization [IDA]
- nucleosome positioning [IDA]
- positive regulation of cell proliferation [IMP]
- regulation of histone H3-K27 methylation [IMP]
- regulation of mitotic cell cycle [IMP]
- segment specification [IMP]
- transcription, DNA-templated [IDA]
Gene Ontology Molecular Function- chromatin binding [NAS]
- histone acetyltransferase binding [IPI, ISS]
- histone binding [IDA, NAS, TAS]
- histone deacetylase binding [IDA, ISS]
- histone methyltransferase activity [IDA]
- histone methyltransferase activity (H3-K27 specific) [IC]
- histone methyltransferase activity (H3-K9 specific) [IC]
- nucleosome binding [IDA]
- protein binding [IPI]
- protein homodimerization activity [IPI]
- chromatin binding [NAS]
- histone acetyltransferase binding [IPI, ISS]
- histone binding [IDA, NAS, TAS]
- histone deacetylase binding [IDA, ISS]
- histone methyltransferase activity [IDA]
- histone methyltransferase activity (H3-K27 specific) [IC]
- histone methyltransferase activity (H3-K9 specific) [IC]
- nucleosome binding [IDA]
- protein binding [IPI]
- protein homodimerization activity [IPI]
Gene Ontology Cellular Component
MTA1-LIKE
Gene Ontology Biological Process
Gene Ontology Cellular Component
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Insight into the architecture of the NuRD complex: structure of the RbAp48-MTA1 subcomplex.
The nucleosome remodeling and deacetylase (NuRD) complex is a widely conserved transcriptional co-regulator that harbors both nucleosome remodeling and histone deacetylase activities. It plays a critical role in the early stages of ES cell differentiation and the reprogramming of somatic to induced pluripotent stem cells. Abnormalities in several NuRD proteins are associated with cancer and aging. We have investigated the ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| CAF1 MTA1-LIKE | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | - | FlyBase | - | |
| CAF1 MTA1-LIKE | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | FlyBase | - | |
| MTA1-LIKE CAF1 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | FlyBase | - | |
| MTA1-LIKE CAF1 | Co-fractionation Co-fractionation Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex. | Low | - | FlyBase | - | |
| MTA1-LIKE CAF1 | Co-fractionation Co-fractionation Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex. | Low | - | FlyBase | - | |
| CAF1 MTA1-LIKE | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | Low | - | BioGRID | - |
Curated By
- BioGRID