PREY

HNRNPDL

HNRNP, HNRPDL, JKTBP, JKTBP2, LGMD1G, laAUF1
heterogeneous nuclear ribonucleoprotein D-like
GO Process (2)
GO Function (5)
GO Component (4)
Homo sapiens

Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

A systems-wide screen identifies substrates of the SCFβTrCP ubiquitin ligase.

Low TY, Peng M, Magliozzi R, Mohammed S, Guardavaccaro D, Heck AJ

Cellular proteins are degraded by the ubiquitin-proteasome system (UPS) in a precise and timely fashion. Such precision is conferred by the high substrate specificity of ubiquitin ligases. Identification of substrates of ubiquitin ligases is crucial not only to unravel the molecular mechanisms by which the UPS controls protein degradation but also for drug discovery purposes because many established UPS substrates ... [more]

Sci Signal Dec. 16, 2014; 7(356);rs8 [Pubmed: 25515538]

Throughput

  • High Throughput

Related interactions

InteractionExperimental Evidence CodeDatasetThroughputScoreCurated ByNotes
FBXW11 HNRNPDL
Affinity Capture-MS
Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

High-BioGRID
1173936

Curated By

  • BioGRID