MCK1
Gene Ontology Biological Process
- ascospore formation [IMP]
- cellular response to heat [IMP]
- cellular response to salt stress [IMP]
- double-strand break repair via nonhomologous end joining [IMP]
- meiotic nuclear division [IMP]
- mitotic sister chromatid segregation [IGI, IMP]
- peptidyl-serine phosphorylation [IDA]
- protein phosphorylation [IDA]
- protein phosphorylation involved in cellular protein catabolic process [IGI, IMP]
Gene Ontology Molecular Function
COG6
Gene Ontology Biological Process
Gene Ontology Cellular Component
Synthetic Growth Defect
A genetic interaction is inferred when mutations in separate genes, each of which alone causes a minimal phenotype, result in a significant growth defect under a given condition when combined in the same cell.
Publication
Differential phosphorylation of a regulatory subunit of protein kinase CK2 by target of rapamycin complex 1 signaling and the Cdc-like kinase Kns1.
Transcriptional regulation of ribosome and tRNA synthesis plays a central role in determining protein synthetic capacity and is tightly controlled in response to nutrient availability and cellular stress. In Saccharomyces cerevisiae, the regulation of ribosome and tRNA synthesis was recently shown to involve the Cdc-like kinase Kns1 and the GSK-3 kinase Mck1. In this study, we explored additional roles for ... [more]
Throughput
- High Throughput
Ontology Terms
- phenotype: vegetative growth (APO:0000106)
- phenotype: resistance to chemicals (APO:0000087)
Additional Notes
- SGA for rapamycin sensitivity using kns1 mck1 double mutant as bait
- Table S1
- genetic complex
- hit shows rapamycin sensitivity in combination with kns1 mck1 double mutant
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| MCK1 COG6 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -0.1344 | BioGRID | 407726 | |
| MCK1 COG6 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -0.16 | BioGRID | 2175540 | |
| COG6 MCK1 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -3.0057 | BioGRID | 325407 | |
| COG6 MCK1 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -4.0619 | BioGRID | 587369 | |
| MCK1 COG6 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -0.134 | BioGRID | 911904 |
Curated By
- BioGRID