BAIT

TINCR

LINC00036, NCRNA00036, PLAC2, PP10933
tissue differentiation-inducing non-protein coding RNA
GO Process (0)
GO Function (0)
GO Component (0)
Homo sapiens
PREY

STAU1

PPP1R150, STAU, RP3-470L14.2
staufen double-stranded RNA binding protein 1
Homo sapiens

Protein-RNA

An interaction is detected between and protein and an RNA in vitro.

Publication

Control of somatic tissue differentiation by the long non-coding RNA TINCR.

Kretz M, Siprashvili Z, Chu C, Webster DE, Zehnder A, Qu K, Lee CS, Flockhart RJ, Groff AF, Chow J, Johnston D, Kim GE, Spitale RC, Flynn RA, Zheng GX, Aiyer S, Raj A, Rinn JL, Chang HY, Khavari PA

Several of the thousands of human long non-coding RNAs (lncRNAs) have been functionally characterized; however, potential roles for lncRNAs in somatic tissue differentiation remain poorly understood. Here we show that a 3.7-kilobase lncRNA, terminal differentiation-induced ncRNA (TINCR), controls human epidermal differentiation by a post-transcriptional mechanism. TINCR is required for high messenger RNA abundance of key differentiation genes, many of which ... [more]

Nature Jan. 10, 2013; 493(7431);231-5 [Pubmed: 23201690]

Throughput

  • Low Throughput

Additional Notes

  • In vitro RNA pull-down using lncRNA TINCR with subsequent STAU1 protein detection

Related interactions

InteractionExperimental Evidence CodeDatasetThroughputScoreCurated ByNotes
TINCR STAU1
Affinity Capture-RNA
Affinity Capture-RNA

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and associated RNA species identified by Northern blot, RT-PCR, affinity labeling, sequencing, or microarray analysis.

Low-BioGRID
1257311
STAU1 TINCR
Protein-RNA
Protein-RNA

An interaction is detected between and protein and an RNA in vitro.

Low-BioGRID
1257306

Curated By

  • BioGRID