BAIT
NTRK1
MTC, TRK, TRK1, TRKA, Trk-A, p140-TrkA
neurotrophic tyrosine kinase, receptor, type 1
GO Process (24)
GO Function (6)
GO Component (7)
Gene Ontology Biological Process
- Ras protein signal transduction [TAS]
- activation of MAPKK activity [TAS]
- activation of adenylate cyclase activity [TAS]
- activation of phospholipase C activity [TAS]
- axonogenesis involved in innervation [ISS]
- cellular response to nerve growth factor stimulus [ISS]
- developmental programmed cell death [ISS]
- negative regulation of cell proliferation [IDA]
- negative regulation of neuron apoptotic process [ISS]
- neurotrophin TRK receptor signaling pathway [IDA, TAS]
- peptidyl-tyrosine phosphorylation [IDA]
- phosphatidylinositol-mediated signaling [TAS]
- positive regulation of ERK1 and ERK2 cascade [IDA]
- positive regulation of NF-kappaB transcription factor activity [IDA]
- positive regulation of Ras GTPase activity [IDA]
- positive regulation of Ras protein signal transduction [IDA]
- positive regulation of angiogenesis [IDA]
- positive regulation of neuron projection development [IDA]
- positive regulation of programmed cell death [ISS]
- protein autophosphorylation [IDA]
- protein phosphorylation [IDA]
- small GTPase mediated signal transduction [TAS]
- sympathetic nervous system development [ISS]
- transmembrane receptor protein tyrosine kinase signaling pathway [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
KIF14
kinesin family member 14
GO Process (32)
GO Function (9)
GO Component (6)
Gene Ontology Biological Process
- ATP catabolic process [IBA, ISS]
- SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [IMP]
- activation of protein kinase activity [IMP]
- cell proliferation in forebrain [ISS]
- cerebellar Purkinje cell layer structural organization [ISS]
- cerebellar cortex development [ISS]
- cerebellar granular layer structural organization [ISS]
- cerebral cortex development [ISS]
- cytoskeleton-dependent intracellular transport [IBA]
- establishment of protein localization [IDA]
- hippocampus development [ISS]
- microtubule depolymerization [ISS]
- microtubule-based movement [IBA]
- mitotic cell cycle process [IMP]
- mitotic metaphase plate congression [IMP]
- negative regulation of apoptotic process [IMP]
- negative regulation of integrin activation [IMP]
- negative regulation of neuron apoptotic process [ISS]
- olfactory bulb development [ISS]
- positive regulation of cell proliferation [IDA, IMP]
- positive regulation of cytokinesis [IMP]
- proteasome-mediated ubiquitin-dependent protein catabolic process [IMP]
- regulation of G1/S transition of mitotic cell cycle [IMP]
- regulation of G2/M transition of mitotic cell cycle [IMP]
- regulation of Rap protein signal transduction [IMP]
- regulation of cell adhesion [IMP]
- regulation of cell growth [IMP]
- regulation of cell migration [IMP]
- regulation of myelination [ISS]
- regulation of neuron apoptotic process [ISS]
- response to docetaxel trihydrate [IMP]
- substrate adhesion-dependent cell spreading [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation.
SH-SY5Y neuroblastoma cells respond to nerve growth factor (NGF)-mediated activation of the tropomyosin-related kinase A (TrkA) with neurite outgrowth, thereby providing a model to study neuronal differentiation. We performed a time-resolved analysis of NGF-TrkA signaling in neuroblastoma cells using mass spectrometry-based quantitative proteomics. The combination of interactome, phosphoproteome, and proteome data provided temporal insights into the molecular events downstream of ... [more]
Sci Signal Apr. 28, 2015; 8(374);ra40 [Pubmed: 25921289]
Throughput
- High Throughput
Curated By
- BioGRID