BAIT

APP

AAA, ABETA, ABPP, AD1, APPI, CTFgamma, CVAP, PN-II, PN2
amyloid beta (A4) precursor protein
GO Process (29)
GO Function (8)
GO Component (21)
Homo sapiens

Reconstituted Complex

An interaction is detected between purified proteins in vitro.

Publication

Protein array based interactome analysis of amyloid-β indicates an inhibition of protein translation.

Virok DP, Simon D, Bozso Z, Rajko R, Datki Z, Balint E, Szegedi V, Janaky T, Penke B, Fueloep L

Oligomeric amyloid-β is currently of interest in amyloid-β mediated toxicity and the pathogenesis of Alzheimer's disease. Mapping the amyloid-β interaction partners could help to discover novel pathways in disease pathogenesis. To discover the amyloid-β interaction partners, we applied a protein array with more than 8100 unique recombinantly expressed human proteins. We identified 324 proteins as potential interactors of oligomeric amyloid-β. ... [more]

J. Proteome Res. Apr. 01, 2011; 10(4);1538-47 [Pubmed: 21244100]

Throughput

  • High Throughput

Additional Notes

  • Oligomeric amyloid-beta queried against the ProtoArray Human Protein Microarray

Curated By

  • BioGRID