BAIT

APP

AAA, ABETA, ABPP, AD1, APPI, CTFgamma, CVAP, PN-II, PN2
amyloid beta (A4) precursor protein
GO Process (29)
GO Function (8)
GO Component (21)
Homo sapiens
PREY

PNRC2

RP11-4M23.5
proline-rich nuclear receptor coactivator 2
GO Process (2)
GO Function (1)
GO Component (2)
Homo sapiens

Reconstituted Complex

An interaction is detected between purified proteins in vitro.

Publication

Protein array based interactome analysis of amyloid-β indicates an inhibition of protein translation.

Virok DP, Simon D, Bozso Z, Rajko R, Datki Z, Balint E, Szegedi V, Janaky T, Penke B, Fueloep L

Oligomeric amyloid-β is currently of interest in amyloid-β mediated toxicity and the pathogenesis of Alzheimer's disease. Mapping the amyloid-β interaction partners could help to discover novel pathways in disease pathogenesis. To discover the amyloid-β interaction partners, we applied a protein array with more than 8100 unique recombinantly expressed human proteins. We identified 324 proteins as potential interactors of oligomeric amyloid-β. ... [more]

J. Proteome Res. Apr. 01, 2011; 10(4);1538-47 [Pubmed: 21244100]

Throughput

  • High Throughput

Additional Notes

  • Oligomeric amyloid-beta queried against the ProtoArray Human Protein Microarray

Curated By

  • BioGRID