BAIT
HSPB2
HSP27, Hs.78846, LOH11CR1K, MKBP
heat shock 27kDa protein 2
GO Process (2)
GO Function (2)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
PREY
DDIT4
Dig2, REDD-1, REDD1, RP11-442H21.1
DNA-damage-inducible transcript 4
GO Process (12)
GO Function (0)
GO Component (2)
Gene Ontology Biological Process
- brain development [ISS]
- cell proliferation [ISS]
- intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [ISS]
- negative regulation of TOR signaling [IMP]
- negative regulation of intracellular signal transduction [ISS]
- negative regulation of peptidyl-serine phosphorylation [ISS]
- negative regulation of peptidyl-threonine phosphorylation [ISS]
- neuron differentiation [ISS]
- neuron migration [ISS]
- neurotrophin TRK receptor signaling pathway [ISS]
- positive regulation of neuron death [ISS]
- response to hypoxia [IDA]
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Characterization of the Cardiac Overexpression of HSPB2 Reveals Mitochondrial and Myogenic Roles Supported by a Cardiac HspB2 Interactome.
Small Heat Shock Proteins (sHSPs) are molecular chaperones that transiently interact with other proteins, thereby assisting with quality control of proper protein folding and/or degradation. They are also recruited to protect cells from a variety of stresses in response to extreme heat, heavy metals, and oxidative-reductive stress. Although ten human sHSPs have been identified, their likely diverse biological functions remain ... [more]
PLoS ONE Oct. 16, 2015; 10(10);e0133994 [Pubmed: 26465331]
Throughput
- High Throughput
Curated By
- BioGRID