SKN7
Gene Ontology Biological Process
Gene Ontology Molecular Function
CRZ1
Gene Ontology Biological Process
- cell wall chitin biosynthetic process [IGI]
- cellular response to blue light [IDA]
- ion homeostasis [IGI, IMP]
- positive regulation of cellular response to drug [IMP]
- positive regulation of sodium ion transport by positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IGI, IMP]
- positive regulation of transcription from RNA polymerase II promoter by calcium-mediated signaling [IGI, IMP]
- positive regulation of transcription from RNA polymerase II promoter by pheromones [IMP]
- positive regulation of transcription from RNA polymerase II promoter in response to alkaline pH [IMP]
- positive regulation of transcription from RNA polymerase II promoter in response to calcium ion [IMP]
- positive regulation of transcription from RNA polymerase II promoter in response to increased salt [IMP]
- regulation of potassium ion concentration by positive regulation of transcription from RNA polymerase II promoter [IDA, IGI, IMP]
Gene Ontology Molecular Function
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
The eukaryotic response regulator Skn7p regulates calcineurin signaling through stabilization of Crz1p.
To survive ionic, pH and pheromone stress, the yeast Saccharomyces cerevisiae activates signaling through the Ca2+-activated phosphatase calcineurin to the transcription factor Crz1p/Tcn1p. We show that the overexpression of SKN7, a response-regulator transcription factor, activates transcription from a calcineurin/Crz1p-dependent response element (CDRE). Ca2+-induced, calcineurin/Crz1p-dependent activation of several genes is reduced in skn7 mutants. Skn7p modulates CDRE-dependent transcription by affecting Crz1p ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| CRZ1 SKN7 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -2.8302 | BioGRID | 508260 |
Curated By
- BioGRID