RORA
Gene Ontology Biological Process
- T-helper 17 cell differentiation [ISS]
- angiogenesis [IMP]
- cellular response to hypoxia [IMP]
- cellular response to sterol [IDA, IMP]
- cerebellar granule cell precursor proliferation [ISS]
- circadian regulation of gene expression [ISS]
- gene expression [TAS]
- intracellular receptor signaling pathway [IDA]
- muscle cell differentiation [IMP]
- negative regulation of I-kappaB kinase/NF-kappaB signaling [IMP]
- negative regulation of fat cell differentiation [ISS]
- negative regulation of inflammatory response [IMP]
- positive regulation of circadian rhythm [ISS]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of transcription, DNA-templated [IDA]
- positive regulation vascular endothelial growth factor production [IMP]
- regulation of cholesterol homeostasis [ISS]
- regulation of glucose metabolic process [ISS]
- regulation of smoothened signaling pathway [ISS]
- regulation of steroid metabolic process [ISS]
- regulation of transcription involved in cell fate commitment [ISS]
- regulation of transcription, DNA-templated [IDA]
- transcription initiation from RNA polymerase II promoter [TAS]
- triglyceride homeostasis [IMP]
- xenobiotic metabolic process [ISS]
Gene Ontology Molecular Function- DNA binding [IDA]
- core promoter sequence-specific DNA binding [IDA]
- direct ligand regulated sequence-specific DNA binding transcription factor activity [IDA]
- oxysterol binding [IDA]
- protein binding [IPI]
- sequence-specific DNA binding [IDA]
- sequence-specific DNA binding transcription factor activity [IDA]
- transcription coactivator binding [IPI]
- transcription corepressor binding [IPI]
- transcription factor binding [IPI]
- DNA binding [IDA]
- core promoter sequence-specific DNA binding [IDA]
- direct ligand regulated sequence-specific DNA binding transcription factor activity [IDA]
- oxysterol binding [IDA]
- protein binding [IPI]
- sequence-specific DNA binding [IDA]
- sequence-specific DNA binding transcription factor activity [IDA]
- transcription coactivator binding [IPI]
- transcription corepressor binding [IPI]
- transcription factor binding [IPI]
Gene Ontology Cellular Component
- nucleoplasm [TAS]
- nucleus [IDA]
NME2
Gene Ontology Biological Process
- CTP biosynthetic process [ISO]
- GTP biosynthetic process [ISO]
- UTP biosynthetic process [ISO]
- integrin-mediated signaling pathway [ISO]
- negative regulation of apoptotic process [ISO]
- negative regulation of myeloid leukocyte differentiation [ISO]
- nucleoside diphosphate phosphorylation [IBA, ISO]
- nucleoside triphosphate biosynthetic process [IBA, ISO]
- positive regulation of cAMP biosynthetic process [ISO]
- positive regulation of epithelial cell proliferation [ISO]
- positive regulation of keratinocyte differentiation [ISO]
- positive regulation of neuron projection development [ISO]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- protein autophosphorylation [ISO]
- protein oligomerization [ISO]
- purine nucleotide metabolic process [IBA]
- pyrimidine nucleotide metabolic process [IBA]
- regulation of apoptotic process [IBA]
- regulation of epidermis development [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
The metastasis suppressor candidate nucleotide diphosphate kinase NM23 specifically interacts with members of the ROR/RZR nuclear orphan receptor subfamily.
We have cloned proteins that interact with the nuclear orphan receptor RZR beta using the yeast two-hybrid system. We identified, amongst a number of other genes, the nucleoside diphosphate kinase (NDPK)-2 also known as Nm23-2, c-myc regulatory factor PuF and differentiation inhibitory factor, RZR beta specifically interacts with Nm23-2 but not with the closely related tumor metastasis suppressor candidate gene ... [more]
Throughput
- Low Throughput
Related interactions
Curated By
- BioGRID