BAIT
ABL2
ABLL, ARG, RP11-177A2.3
ABL proto-oncogene 2, non-receptor tyrosine kinase
GO Process (21)
GO Function (9)
GO Component (3)
Gene Ontology Biological Process
- axon guidance [TAS]
- cell migration [IBA]
- cellular protein modification process [TAS]
- cellular response to retinoic acid [IMP]
- epidermal growth factor receptor signaling pathway [IBA]
- innate immune response [IBA]
- peptidyl-tyrosine autophosphorylation [IBA]
- peptidyl-tyrosine phosphorylation [IDA]
- platelet-derived growth factor receptor signaling pathway [IBA]
- positive regulation of cytosolic calcium ion concentration [IMP]
- positive regulation of neuron projection development [IMP]
- positive regulation of oxidoreductase activity [IDA]
- positive regulation of phospholipase C activity [IMP]
- regulation of actin cytoskeleton reorganization [TAS]
- regulation of apoptotic process [IBA]
- regulation of autophagy [TAS]
- regulation of cell adhesion [TAS]
- regulation of cell motility [TAS]
- regulation of cell proliferation [IBA]
- regulation of endocytosis [TAS]
- signal transduction [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
PIK3R3
p55, p55-GAMMA, RP4-533D7.2
phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
GO Process (5)
GO Function (2)
GO Component (1)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Phospho-tyrosine dependent protein-protein interaction network.
Post-translational protein modifications, such as tyrosine phosphorylation, regulate protein-protein interactions (PPIs) critical for signal processing and cellular phenotypes. We extended an established yeast two-hybrid system employing human protein kinases for the analyses of phospho-tyrosine (pY)-dependent PPIs in a direct experimental, large-scale approach. We identified 292 mostly novel pY-dependent PPIs which showed high specificity with respect to kinases and interacting proteins ... [more]
Mol. Syst. Biol. Mar. 01, 2015; 11(3);794 [Pubmed: 25814554]
Throughput
- High Throughput
Additional Notes
- phospho-tyrosine dependent, interaction occurs in the presence of a kinase
Curated By
- BioGRID