BAIT
MAPK8IP2
IB-2, IB2, JIP2, PRKM8IPL
mitogen-activated protein kinase 8 interacting protein 2
GO Process (14)
GO Function (7)
GO Component (2)
Gene Ontology Biological Process
- MAPK cascade [IDA]
- behavioral fear response [ISS]
- dendrite morphogenesis [ISS]
- nonassociative learning [ISS]
- positive regulation of protein kinase activity [IDA, IGI]
- positive regulation of signal transduction [NAS]
- regulation of JNK cascade [IDA]
- regulation of N-methyl-D-aspartate selective glutamate receptor activity [ISS]
- regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity [ISS]
- regulation of excitatory postsynaptic membrane potential [ISS]
- regulation of receptor activity [ISS]
- regulation of synaptic transmission, glutamatergic [ISS]
- signal complex assembly [TAS]
- social behavior [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
CTNNBL1
C20orf33, NAP, P14L, PP8304, dJ633O20.1, RP5-1118M15.1
catenin, beta like 1
GO Process (2)
GO Function (2)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Phospho-tyrosine dependent protein-protein interaction network.
Post-translational protein modifications, such as tyrosine phosphorylation, regulate protein-protein interactions (PPIs) critical for signal processing and cellular phenotypes. We extended an established yeast two-hybrid system employing human protein kinases for the analyses of phospho-tyrosine (pY)-dependent PPIs in a direct experimental, large-scale approach. We identified 292 mostly novel pY-dependent PPIs which showed high specificity with respect to kinases and interacting proteins ... [more]
Mol. Syst. Biol. Mar. 01, 2015; 11(3);794 [Pubmed: 25814554]
Throughput
- High Throughput
Curated By
- BioGRID