RARA
Gene Ontology Biological Process
- apoptotic cell clearance [IMP]
- cellular response to estrogen stimulus [IDA]
- cellular response to retinoic acid [IDA]
- gene expression [TAS]
- intracellular estrogen receptor signaling pathway [IDA]
- negative regulation of granulocyte differentiation [IDA]
- negative regulation of interferon-gamma production [IDA]
- negative regulation of transcription, DNA-templated [IDA]
- negative regulation of tumor necrosis factor production [IDA]
- positive regulation of T-helper 2 cell differentiation [IDA]
- positive regulation of binding [IMP]
- positive regulation of cell cycle [IMP]
- positive regulation of cell proliferation [IMP]
- positive regulation of interleukin-13 production [IDA]
- positive regulation of interleukin-4 production [IDA]
- positive regulation of interleukin-5 production [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IMP]
- positive regulation of transcription, DNA-templated [IDA, IMP]
- protein phosphorylation [IMP]
- response to estradiol [IDA]
- response to retinoic acid [IMP]
- retinoic acid receptor signaling pathway [IMP]
- signal transduction [IDA]
- transcription initiation from RNA polymerase II promoter [TAS]
Gene Ontology Molecular Function- chromatin DNA binding [IDA]
- enzyme binding [IPI]
- protein binding [IPI]
- protein domain specific binding [IPI]
- protein heterodimerization activity [IDA]
- protein kinase A binding [IDA]
- protein kinase B binding [IPI]
- receptor binding [IDA]
- retinoic acid binding [IDA]
- retinoic acid receptor activity [IDA]
- retinoic acid-responsive element binding [IDA]
- sequence-specific DNA binding transcription factor activity [IDA]
- transcription coactivator activity [IDA, IMP]
- transcription corepressor activity [IDA]
- transcription factor binding [IPI]
- chromatin DNA binding [IDA]
- enzyme binding [IPI]
- protein binding [IPI]
- protein domain specific binding [IPI]
- protein heterodimerization activity [IDA]
- protein kinase A binding [IDA]
- protein kinase B binding [IPI]
- receptor binding [IDA]
- retinoic acid binding [IDA]
- retinoic acid receptor activity [IDA]
- retinoic acid-responsive element binding [IDA]
- sequence-specific DNA binding transcription factor activity [IDA]
- transcription coactivator activity [IDA, IMP]
- transcription corepressor activity [IDA]
- transcription factor binding [IPI]
Gene Ontology Cellular Component
SRF
Gene Ontology Biological Process
- angiogenesis involved in wound healing [TAS]
- cell migration involved in sprouting angiogenesis [IMP]
- cellular senescence [IMP]
- heart development [ISS]
- heart looping [ISS]
- mRNA transcription from RNA polymerase II promoter [ISS]
- muscle cell cellular homeostasis [ISS]
- negative regulation of beta-amyloid clearance [IMP]
- neuron development [TAS]
- positive regulation of cell differentiation [IDA]
- positive regulation of sequence-specific DNA binding transcription factor activity [IDA]
- positive regulation of smooth muscle contraction [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation [IGI]
- positive regulation of transcription initiation from RNA polymerase II promoter [IDA]
- positive regulation of transcription via serum response element binding [IDA]
- regulation of smooth muscle cell differentiation [TAS]
- response to cytokine [IMP, NAS]
- response to hormone [IDA]
- response to hypoxia [IEP]
- response to toxic substance [TAS]
- transcription from RNA polymerase II promoter [IDA]
- trophectodermal cell differentiation [IDA]
Gene Ontology Molecular Function- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISS]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity [IMP]
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISS]
- protein binding [IPI]
- protein homodimerization activity [IPI]
- sequence-specific DNA binding transcription factor activity [IDA]
- serum response element binding [IDA]
- transcription factor binding [IPI]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISS]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity [IMP]
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISS]
- protein binding [IPI]
- protein homodimerization activity [IPI]
- sequence-specific DNA binding transcription factor activity [IDA]
- serum response element binding [IDA]
- transcription factor binding [IPI]
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Retinoid-dependent antagonism of serum response factor transactivation mediated by transcriptional coactivator proteins.
Transcriptional coactivators SRC-1 and p300 specifically interact with liganded-nuclear receptors and also modulate other transcription factors, including serum response factor (SRF). Here, we report that retinoids repress transactivation by SRF and specific interactions exist between the DNA binding domains of SRF and retinoic acid and retinoid X receptors. We further demonstrate that the repression may involve retinoid-dependent competition for a ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| RARA SRF | Reconstituted Complex Reconstituted Complex An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator. | Low | - | BioGRID | - |
Curated By
- BioGRID