MRE11
Gene Ontology Biological Process
- DNA catabolic process, endonucleolytic [TAS]
- DNA double-strand break processing [IGI, IMP]
- cellular protein localization [IMP]
- double-strand break repair [IMP]
- double-strand break repair via nonhomologous end joining [IMP]
- intra-S DNA damage checkpoint [IMP]
- meiotic DNA double-strand break formation [TAS]
- meiotic gene conversion [IDA]
- mitotic DNA damage checkpoint [IMP]
- reciprocal meiotic recombination [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
REC12
Gene Ontology Biological Process
Gene Ontology Molecular Function
Phenotypic Suppression
A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.
Publication
Conserved and nonconserved proteins for meiotic DNA breakage and repair in yeasts.
During meiosis DNA double-strand breaks initiate recombination in the distantly related budding and fission yeasts and perhaps in most eukaryotes. Repair of broken meiotic DNA is essential for formation of viable gametes. We report here distinct but overlapping sets of proteins in these yeasts required for formation and repair of double-strand breaks. Meiotic DNA breakage in Schizosaccharomyces pombe did not ... [more]
Throughput
- Low Throughput
Ontology Terms
- phenotype: sporulation efficiency (APO:0000044)
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| MRE11 REC12 | Dosage Rescue Dosage Rescue A genetic interaction is inferred when over expression or increased dosage of one gene rescues the lethality or growth defect of a strain that is mutated or deleted for another gene. | Low | - | PomBase | - | |
| MRE11 REC12 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -3.69 | BioGRID | 522427 | |
| REC12 MRE11 | Phenotypic Suppression Phenotypic Suppression A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene. | Low | - | BioGRID | 248033 | |
| MRE11 REC12 | Phenotypic Suppression Phenotypic Suppression A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene. | Low | - | BioGRID | 795618 |
Curated By
- BioGRID