MRE11
Gene Ontology Biological Process
- DNA catabolic process, endonucleolytic [TAS]
- DNA double-strand break processing [IGI, IMP]
- cellular protein localization [IMP]
- double-strand break repair [IMP]
- double-strand break repair via nonhomologous end joining [IMP]
- intra-S DNA damage checkpoint [IMP]
- meiotic DNA double-strand break formation [TAS]
- meiotic gene conversion [IDA]
- mitotic DNA damage checkpoint [IMP]
- reciprocal meiotic recombination [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
REC12
Gene Ontology Biological Process
Gene Ontology Molecular Function
Phenotypic Suppression
A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.
Publication
A novel recombination pathway initiated by the Mre11/Rad50/Nbs1 complex eliminates palindromes during meiosis in Schizosaccharomyces pombe.
DNA palindromes are rare in humans but are associated with meiosis-specific translocations. The conserved Mre11/Rad50/Nbs1 (MRN) complex is likely directly involved in processing palindromes through the homologous recombination pathway of DNA repair. Using the fission yeast Schizosaccharomyces pombe as a model system, we show that a 160-bp palindrome (M-pal) is a meiotic recombination hotspot and is preferentially eliminated by gene ... [more]
Throughput
- Low Throughput
Ontology Terms
- sporulation efficiency (APO:0000044)
Additional Notes
- The very low viable spore yield in rad32-D65N crosses was suppressed in the absence of Rec12
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| MRE11 REC12 | Dosage Rescue Dosage Rescue A genetic interaction is inferred when over expression or increased dosage of one gene rescues the lethality or growth defect of a strain that is mutated or deleted for another gene. | Low | - | PomBase | - | |
| MRE11 REC12 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -3.69 | BioGRID | 522427 | |
| REC12 MRE11 | Phenotypic Suppression Phenotypic Suppression A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene. | Low | - | BioGRID | 248033 | |
| MRE11 REC12 | Phenotypic Suppression Phenotypic Suppression A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene. | Low | - | BioGRID | 1417373 |
Curated By
- BioGRID