BAIT
EWSR1
EWS, bK984G1.4, AC002059.7
EWS RNA-binding protein 1
GO Process (0)
GO Function (4)
GO Component (3)
Gene Ontology Molecular Function
Homo sapiens
PREY
KIF2A
CDCBM3, HK2, KIF2
kinesin heavy chain member 2A
GO Process (9)
GO Function (4)
GO Component (6)
Gene Ontology Biological Process
- ATP catabolic process [IBA]
- antigen processing and presentation of exogenous peptide antigen via MHC class II [TAS]
- blood coagulation [TAS]
- metabolic process [IBA, TAS]
- microtubule depolymerization [IBA]
- microtubule-based movement [IBA, TAS]
- mitotic cell cycle [TAS]
- mitotic spindle organization [IDA]
- spindle assembly involved in mitosis [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Proteomic Analysis of the EWS-Fli-1 Interactome Reveals the Role of the Lysosome in EWS-Fli-1 Turnover.
Ewing sarcoma is a cancer of bone and soft tissue in children that is characterized by a chromosomal translocation involving EWS and an Ets family transcription factor, most commonly Fli-1. EWS-Fli-1 fusion accounts for 85% of cases. The growth and survival of Ewing sarcoma cells are critically dependent on EWS-Fli-1. A large body of evidence has established that EWS-Fli-1 functions ... [more]
J. Proteome Res. Aug. 01, 2014; 13(8);3783-91 [Pubmed: 24999758]
Throughput
- High Throughput
Curated By
- BioGRID