STX6
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
STX4
Gene Ontology Biological Process
- blood coagulation [TAS]
- intracellular protein transport [IBA]
- long-term synaptic potentiation [IDA]
- membrane organization [TAS]
- organelle fusion [IDA]
- platelet activation [TAS]
- positive regulation of catalytic activity [IMP]
- positive regulation of cell adhesion [IMP]
- positive regulation of cell migration [IMP]
- positive regulation of cell proliferation [IMP]
- positive regulation of chemotaxis [IMP]
- positive regulation of eosinophil degranulation [IMP]
- positive regulation of establishment of protein localization to plasma membrane [IMP]
- positive regulation of immunoglobulin secretion [IMP]
- positive regulation of insulin secretion involved in cellular response to glucose stimulus [IDA, IMP]
- positive regulation of protein localization to cell surface [IMP]
- positive regulation of protein localization to plasma membrane [IMP]
- post-Golgi vesicle-mediated transport [TAS]
- regulation of exocytosis [IMP]
- regulation of extrinsic apoptotic signaling pathway via death domain receptors [IMP]
- response to hydroperoxide [IDA]
- synaptic vesicle fusion to presynaptic membrane [IBA]
- vesicle docking [IBA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- SNARE complex [IDA]
- basolateral plasma membrane [IDA]
- cell surface [IDA]
- cytosol [TAS]
- dendritic spine [IDA]
- endosome [IDA]
- extracellular space [IDA]
- extracellular vesicular exosome [IDA]
- integral component of membrane [IBA]
- intracellular [IDA]
- lamellipodium [IDA]
- membrane [IDA]
- plasma membrane [IDA, TAS]
- somatodendritic compartment [IDA]
- specific granule [IDA]
- synapse [IDA]
- synaptic vesicle [IBA]
- vacuole [TAS]
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Next-generation sequencing to generate interactome datasets.
Next-generation sequencing has not been applied to protein-protein interactome network mapping so far because the association between the members of each interacting pair would not be maintained in en masse sequencing. We describe a massively parallel interactome-mapping pipeline, Stitch-seq, that combines PCR stitching with next-generation sequencing and used it to generate a new human interactome dataset. Stitch-seq is applicable to ... [more]
Throughput
- High Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| STX6 STX4 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.9935 | BioGRID | 1177088 | |
| STX6 STX4 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.9827 | BioGRID | 2244137 | |
| STX6 STX4 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.9745 | BioGRID | 3068639 | |
| STX4 STX6 | Proximity Label-MS Proximity Label-MS An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods. | High | 30 | BioGRID | 3007786 | |
| STX4 STX6 | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | High | - | BioGRID | 2708208 | |
| STX4 STX6 | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | High | - | BioGRID | - |
Curated By
- BioGRID