BAIT
CHEK1
C85740, Chk1, rad27
checkpoint kinase 1
GO Process (19)
GO Function (4)
GO Component (9)
Gene Ontology Biological Process
- DNA damage checkpoint [IDA, IMP, ISO]
- DNA damage induced protein phosphorylation [ISO]
- DNA repair [IDA, ISO]
- G2 DNA damage checkpoint [ISO]
- G2/M transition of mitotic cell cycle [IMP]
- cellular response to DNA damage stimulus [IDA, ISO]
- chromatin-mediated maintenance of transcription [IMP]
- histone H3-T11 phosphorylation [ISO]
- negative regulation of DNA biosynthetic process [ISO]
- negative regulation of G2/M transition of mitotic cell cycle [ISO]
- negative regulation of mitosis [ISO]
- peptidyl-threonine phosphorylation [ISO]
- protein phosphorylation [IDA, IMP, ISO]
- regulation of cell proliferation [IMP]
- regulation of double-strand break repair via homologous recombination [ISO]
- regulation of gene expression [IGI]
- regulation of histone H3-K9 acetylation [IDA]
- regulation of mitotic centrosome separation [ISO]
- regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
ACSL3
ACS3, FACL3, PRO2194
acyl-CoA synthetase long-chain family member 3
GO Process (6)
GO Function (3)
GO Component (5)
Gene Ontology Biological Process
- long-chain fatty acid import [IDA]
- long-chain fatty acid metabolic process [IMP]
- positive regulation of Golgi to plasma membrane protein transport [IMP]
- positive regulation of phosphatidylcholine biosynthetic process [IMP]
- positive regulation of secretion [IMP]
- very-low-density lipoprotein particle assembly [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
A Human Interactome in Three Quantitative Dimensions Organized by Stoichiometries and Abundances.
The organization of a cell emerges from the interactions in protein networks. The interactome is critically dependent on the strengths of interactions and the cellular abundances of the connected proteins, both of which span orders of magnitude. However, these aspects have not yet been analyzed globally. Here, we have generated a library of HeLa cell lines expressing 1,125 GFP-tagged proteins ... [more]
Cell Oct. 22, 2015; 163(3);712-23 [Pubmed: 26496610]
Throughput
- High Throughput
Additional Notes
- interaction detected by quantitative BAC-GFP interactomics (QUBIC)
Curated By
- BioGRID