SIW14
Gene Ontology Biological Process
Gene Ontology Molecular Function
VIP1
Gene Ontology Biological Process
Gene Ontology Molecular Function
Phenotypic Enhancement
A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.
Publication
A novel inositol pyrophosphate phosphatase in Saccharomyces cerevisiae: Siw14 selectively cleaves the β-phosphate from 5-diphosphoinositol pentakisphosphate (5PP-IP5).
Inositol pyrophosphates are high energy signaling molecules involved in cellular processes such as energetic metabolism, telomere maintenance, stress responses, vesicle trafficking, and can mediate protein phosphorylation. While the inositol kinases underlying inositol pyrophosphate biosynthesis and are well characterized, the phosphatases that selectively regulate their cellular pools are not fully described. The DIPP (diphosphoinositol phosphate phosphohydrolase) enzymes of the Nudix protein ... [more]
Throughput
- Low Throughput
Ontology Terms
- phenotype: chemical compound accumulation (APO:0000095)
Additional Notes
- Figure 8
- double mutants show increase in inositol phosphates
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
VIP1 SIW14 | Positive Genetic Positive Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a less severe fitness defect than expected under a given condition. This term is reserved for high or low throughput studies with scores. | High | 0.1913 | BioGRID | 1912360 | |
VIP1 SIW14 | Positive Genetic Positive Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a less severe fitness defect than expected under a given condition. This term is reserved for high or low throughput studies with scores. | High | 3.8861 | BioGRID | 325096 |
Curated By
- BioGRID