BAIT
MAP1LC3A
ATG8E, LC3, LC3A, MAP1ALC3, MAP1BLC3, RP11-346K17.1
microtubule-associated protein 1 light chain 3 alpha
GO Process (5)
GO Function (5)
GO Component (6)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
TRIM21
RNF81, RO52, Ro/SSA, SSA, SSA1
tripartite motif containing 21
GO Process (15)
GO Function (3)
GO Component (6)
Gene Ontology Biological Process
- innate immune response [IDA, TAS]
- negative regulation of NF-kappaB transcription factor activity [IDA]
- negative regulation of protein deubiquitination [IMP]
- negative regulation of viral release from host cell [IDA]
- negative regulation of viral transcription [IDA]
- positive regulation of cell cycle [IMP]
- positive regulation of sequence-specific DNA binding transcription factor activity [IDA]
- positive regulation of type I interferon production [TAS]
- protein autoubiquitination [IDA]
- protein destabilization [IMP]
- protein monoubiquitination [IDA]
- protein polyubiquitination [IDA]
- protein trimerization [IDA]
- protein ubiquitination [IDA]
- regulation of type I interferon production [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
TRIM-mediated precision autophagy targets cytoplasmic regulators of innate immunity.
The present paradigms of selective autophagy in mammalian cells cannot fully explain the specificity and selectivity of autophagic degradation. In this paper, we report that a subset of tripartite motif (TRIM) proteins act as specialized receptors for highly specific autophagy (precision autophagy) of key components of the inflammasome and type I interferon response systems. TRIM20 targets the inflammasome components, including ... [more]
J. Cell Biol. Sep. 14, 2015; 210(6);973-89 [Pubmed: 26347139]
Throughput
- Low Throughput
Curated By
- BioGRID