An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

The scaffold protein KSR1, a novel therapeutic target for the treatment of Merlin-deficient tumors.

Zhou L, Lyons-Rimmer J, Ammoun S, Mueller J, Lasonder E, Sharma V, Ercolano E, Hilton D, Taiwo I, Barczyk M, Hanemann CO

Merlin has broad tumor-suppressor functions as its mutations have been identified in multiple benign tumors and malignant cancers. In all schwannomas, the majority of meningiomas and 1/3 of ependymomas Merlin loss is causative. In neurofibromatosis type 2, a dominantly inherited tumor disease because of the loss of Merlin, patients suffer from multiple nervous system tumors and die on average around ... [more]

Oncogene Nov. 09, 2015; 0(0); [Pubmed: 26549023]

Throughput

High Throughput

Additional Notes

Table S1

Related interactions

Interaction	Experimental Evidence Code	Dataset	Throughput	Score	Curated By	Notes
KSR1 HSPA4	Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.	Stewart S (1999)	Low	-	BioGRID	-

Curated By

BioGRID

Interaction Summary

KSR1

Gene Ontology Biological Process

Gene Ontology Molecular Function

MAP-kinase scaffold activity [IDA]mitogen-activated protein kinase kinase binding [ISO]protein C-terminus binding [ISO]protein binding [IPI]

Gene Ontology Cellular Component

HSPA4