BAIT
RHOU
ARHU, CDC42L1, G28K, WRCH1, hG28K, SB128
ras homolog family member U
GO Process (4)
GO Function (1)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
EIF4B
EIF-4B, PRO1843
eukaryotic translation initiation factor 4B
GO Process (10)
GO Function (3)
GO Component (2)
Gene Ontology Biological Process
- RNA metabolic process [TAS]
- cellular protein metabolic process [TAS]
- gene expression [TAS]
- insulin receptor signaling pathway [TAS]
- mRNA metabolic process [TAS]
- nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [TAS]
- nuclear-transcribed mRNA poly(A) tail shortening [TAS]
- regulation of translational initiation [TAS]
- translation [TAS]
- translational initiation [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
PAK4 promotes kinase-independent stabilization of RhoU to modulate cell adhesion.
P21-activated kinase 4 (PAK4) is a Cdc42 effector protein thought to regulate cell adhesion disassembly in a kinase-dependent manner. We found that PAK4 expression is significantly higher in high-grade human breast cancer patient samples, whereas depletion of PAK4 modifies cell adhesion dynamics of breast cancer cells. Surprisingly, systematic analysis of PAK4 functionality revealed that PAK4-driven adhesion turnover is neither dependent ... [more]
J. Cell Biol. Nov. 23, 2015; 211(4);863-79 [Pubmed: 26598620]
Throughput
- High Throughput
Additional Notes
- Table S1
- identified via protein microarray
Curated By
- BioGRID