HTT
Gene Ontology Biological Process
- Golgi organization [IMP]
- establishment of mitotic spindle orientation [IMP]
- negative regulation of extrinsic apoptotic signaling pathway [IMP]
- organ development [IBA]
- positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity [IDA]
- regulation of protein phosphatase type 2A activity [IMP]
- retrograde vesicle-mediated transport, Golgi to ER [IMP]
- vesicle transport along microtubule [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
HAP1
Gene Ontology Biological Process
- anterograde axon cargo transport [IMP, ISO]
- cerebellum development [IMP]
- hypothalamus cell differentiation [IMP]
- negative regulation of beta-amyloid formation [ISO]
- neuron projection development [ISO]
- neurotrophin TRK receptor signaling pathway [IMP]
- positive regulation of epidermal growth factor receptor signaling pathway [ISO]
- positive regulation of inclusion body assembly [ISO]
- positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity [IMP, ISO]
- positive regulation of neurogenesis [IMP]
- positive regulation of neuron projection development [ISO]
- positive regulation of neurotrophin production [ISO]
- positive regulation of nonmotile primary cilium assembly [IMP]
- positive regulation of synaptic transmission, GABAergic [ISO]
- protein localization [ISO]
- regulation of exocytosis [IMP]
- regulation of organelle transport along microtubule [IMP]
- retrograde axon cargo transport [ISO]
- vesicle transport along microtubule [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Huntingtin functions as a scaffold for selective macroautophagy.
Selective macroautophagy is an important protective mechanism against diverse cellular stresses. In contrast to the well-characterized starvation-induced autophagy, the regulation of selective autophagy is largely unknown. Here, we demonstrate that Huntingtin, the Huntington disease gene product, functions as a scaffold protein for selective macroautophagy but it is dispensable for non-selective macroautophagy. In Drosophila, Huntingtin genetically interacts with autophagy pathway components. ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID