BAIT
PES1
PES
pescadillo ribosomal biogenesis factor 1
GO Process (6)
GO Function (2)
GO Component (7)
Gene Ontology Biological Process
- cell proliferation [IMP, NAS]
- maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [IMP]
- maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [IMP]
- rRNA processing [IMP]
- regulation of cell cycle [IMP]
- ribosomal large subunit biogenesis [IC]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
BUB3
BUB3L, hBUB3
BUB3 mitotic checkpoint protein
GO Process (7)
GO Function (1)
GO Component (3)
Gene Ontology Biological Process
- anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process [TAS]
- attachment of spindle microtubules to kinetochore [IDA]
- mitotic cell cycle [TAS]
- mitotic spindle assembly checkpoint [TAS]
- negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [TAS]
- regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [TAS]
- spindle assembly checkpoint [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
DEAD-box helicase DDX27 regulates 3' end formation of ribosomal 47S RNA and stably associates with the PeBoW-complex.
PeBoW, a trimeric complex consisting of pescadillo (Pes1), block of proliferation (Bop1), and the WD repeat protein 12 (WDR12), is essential for processing and maturation of mammalian 5.8S and 28S ribosomal RNAs. Applying a mass spectrometric analysis, we identified the DEAD-box helicase DDX27 as stably associated factor of the PeBoW-complex. DDX27 interacts with the PeBoW-complex via an evolutionary conserved F×F ... [more]
Exp. Cell Res. May. 15, 2015; 334(1);146-59 [Pubmed: 25825154]
Throughput
- Low Throughput
Curated By
- BioGRID