TRAF3
Gene Ontology Biological Process
- negative regulation of NF-kappaB transcription factor activity [IMP, ISO, TAS]
- regulation of cytokine production [IMP]
- regulation of defense response to virus [IMP]
- regulation of interferon-beta production [IMP]
- regulation of proteolysis [IDA, IMP, ISO]
- toll-like receptor signaling pathway [IMP]
- tumor necrosis factor-mediated signaling pathway [IMP, ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
PYCARD
Gene Ontology Biological Process
- activation of cysteine-type endopeptidase activity involved in apoptotic process [IMP]
- activation of innate immune response [IMP, ISO]
- apoptotic process [ISO]
- cellular response to interleukin-1 [ISO]
- cellular response to lipopolysaccharide [ISO]
- cellular response to tumor necrosis factor [ISO]
- defense response to Gram-negative bacterium [ISO]
- defense response to virus [ISO]
- inflammatory response [IMP]
- interleukin-1 beta production [IGI]
- intrinsic apoptotic signaling pathway by p53 class mediator [ISO]
- intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [ISO]
- macropinocytosis [IMP]
- myeloid dendritic cell activation [ISO]
- myeloid dendritic cell activation involved in immune response [IMP]
- negative regulation of I-kappaB kinase/NF-kappaB signaling [ISO]
- negative regulation of NF-kappaB transcription factor activity [ISO]
- negative regulation of interferon-beta production [ISO]
- negative regulation of protein serine/threonine kinase activity [ISO]
- positive regulation of ERK1 and ERK2 cascade [IMP, ISO]
- positive regulation of JNK cascade [ISO]
- positive regulation of NF-kappaB transcription factor activity [ISO]
- positive regulation of T cell activation [ISO]
- positive regulation of T cell migration [IMP]
- positive regulation of actin filament polymerization [IMP]
- positive regulation of activated T cell proliferation [IMP]
- positive regulation of adaptive immune response [ISO]
- positive regulation of antigen processing and presentation of peptide antigen via MHC class II [IMP]
- positive regulation of apoptotic process [ISO]
- positive regulation of chemokine secretion [IMP, ISO]
- positive regulation of cysteine-type endopeptidase activity [ISO]
- positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [ISO]
- positive regulation of defense response to virus by host [IMP]
- positive regulation of extrinsic apoptotic signaling pathway [ISO]
- positive regulation of interferon-gamma production [IMP]
- positive regulation of interleukin-1 beta secretion [IGI, IMP, ISO]
- positive regulation of interleukin-10 secretion [ISO]
- positive regulation of interleukin-6 production [IMP]
- positive regulation of interleukin-6 secretion [ISO]
- positive regulation of interleukin-8 secretion [ISO]
- positive regulation of phagocytosis [IMP]
- positive regulation of release of cytochrome c from mitochondria [ISO]
- positive regulation of sequence-specific DNA binding transcription factor activity [ISO]
- positive regulation of tumor necrosis factor production [ISO]
- regulation of Rac GTPase activity [IMP]
- regulation of apoptotic process [IMP]
- regulation of autophagy [IMP]
- regulation of cysteine-type endopeptidase activity involved in apoptotic process [IMP]
- regulation of inflammatory response [IMP]
- regulation of intrinsic apoptotic signaling pathway [ISO]
- regulation of protein stability [IMP]
- regulation of tumor necrosis factor-mediated signaling pathway [ISO]
- response to bacterium [IMP]
- tumor necrosis factor-mediated signaling pathway [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
MAVS Promotes Inflammasome Activation by Targeting ASC for K63-Linked Ubiquitination via the E3 Ligase TRAF3.
Stringent control of inflammasome signaling pathway is important for maintaining immunological balance, yet the molecular mechanisms responsible for its tight regulation are still poorly understood. In this study, we found that the signaling pathway dependent on mitochondrial antiviral signaling protein (MAVS) was required for the optimal activation of apoptosis-associated specklike protein (ASC)-dependent inflammasome. In particular, TNFR-associated factor 3 was found ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| TRAF3 PYCARD | Co-fractionation Co-fractionation Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex. | Low | - | BioGRID | - |
Curated By
- BioGRID