NOD2
Gene Ontology Biological Process
- JNK cascade [TAS]
- MyD88-dependent toll-like receptor signaling pathway [TAS]
- MyD88-independent toll-like receptor signaling pathway [TAS]
- TRIF-dependent toll-like receptor signaling pathway [TAS]
- activation of MAPK activity [TAS]
- activation of MAPK activity involved in innate immune response [ISS]
- cellular response to muramyl dipeptide [IDA]
- cytokine production involved in immune response [IMP]
- defense response [TAS]
- defense response to bacterium [IDA]
- detection of bacterium [IDA]
- detection of biotic stimulus [TAS]
- detection of muramyl dipeptide [IDA]
- innate immune response [IDA, NAS, TAS]
- intracellular signal transduction [IDA]
- maintenance of gastrointestinal epithelium [IMP]
- negative regulation of macrophage apoptotic process [ISS]
- nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway [TAS]
- nucleotide-binding oligomerization domain containing 2 signaling pathway [IDA]
- nucleotide-binding oligomerization domain containing signaling pathway [TAS]
- positive regulation of B cell activation [IDA]
- positive regulation of ERK1 and ERK2 cascade [ISS]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IDA]
- positive regulation of JNK cascade [IDA]
- positive regulation of NF-kappaB transcription factor activity [IDA, TAS]
- positive regulation of Notch signaling pathway [ISS]
- positive regulation of dendritic cell antigen processing and presentation [ISS]
- positive regulation of epithelial cell proliferation [ISS]
- positive regulation of gamma-delta T cell activation [ISS]
- positive regulation of interleukin-1 beta production [IMP]
- positive regulation of interleukin-1 beta secretion [IDA]
- positive regulation of interleukin-10 production [ISS]
- positive regulation of interleukin-17 production [IMP]
- positive regulation of interleukin-6 production [IDA]
- positive regulation of nitric-oxide synthase biosynthetic process [ISS]
- positive regulation of oxidoreductase activity [ISS]
- positive regulation of phosphatidylinositol 3-kinase activity [ISS]
- positive regulation of prostaglandin-E synthase activity [ISS]
- positive regulation of prostaglandin-endoperoxide synthase activity [ISS]
- positive regulation of stress-activated MAPK cascade [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of tumor necrosis factor production [IDA, IMP]
- positive regulation of type 2 immune response [IMP]
- protein oligomerization [TAS]
- regulation of inflammatory response [IC]
- response to muramyl dipeptide [IDA]
- stress-activated MAPK cascade [TAS]
- toll-like receptor 10 signaling pathway [TAS]
- toll-like receptor 2 signaling pathway [TAS]
- toll-like receptor 3 signaling pathway [TAS]
- toll-like receptor 4 signaling pathway [TAS]
- toll-like receptor 5 signaling pathway [TAS]
- toll-like receptor 9 signaling pathway [TAS]
- toll-like receptor TLR1:TLR2 signaling pathway [TAS]
- toll-like receptor TLR6:TLR2 signaling pathway [TAS]
- toll-like receptor signaling pathway [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
CYLD
Gene Ontology Biological Process
- cytoplasmic translation [IBA]
- innate immune response [TAS]
- necroptotic process [IBA]
- negative regulation of NF-kappaB import into nucleus [IDA]
- negative regulation of NF-kappaB transcription factor activity [IDA]
- negative regulation of canonical Wnt signaling pathway [IMP]
- negative regulation of type I interferon production [TAS]
- nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway [TAS]
- nucleotide-binding oligomerization domain containing signaling pathway [TAS]
- positive regulation of extrinsic apoptotic signaling pathway [IMP]
- protein K63-linked deubiquitination [IDA]
- regulation of cilium assembly [ISS]
- regulation of intrinsic apoptotic signaling pathway [IMP]
- regulation of microtubule cytoskeleton organization [IMP]
- regulation of mitotic cell cycle [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
LUBAC-Recruited CYLD and A20 Regulate Gene Activation and Cell Death by Exerting Opposing Effects on Linear Ubiquitin in Signaling Complexes.
Ubiquitination and deubiquitination are crucial for assembly and disassembly of signaling complexes. LUBAC-generated linear (M1) ubiquitin is important for signaling via various immune receptors. We show here that the deubiquitinases CYLD and A20, but not OTULIN, are recruited to the TNFR1- and NOD2-associated signaling complexes (TNF-RSC and NOD2-SC), at which they cooperate to limit gene activation. Whereas CYLD recruitment depends ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| NOD2 CYLD | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID