CDC37
Gene Ontology Biological Process
Gene Ontology Molecular Function
RPS6KA6
Gene Ontology Biological Process
- DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator [IMP]
- axon guidance [TAS]
- central nervous system development [TAS]
- negative regulation of ERK1 and ERK2 cascade [ISS]
- negative regulation of embryonic development [ISS]
- negative regulation of mesoderm development [ISS]
- signal transduction [TAS]
- synaptic transmission [TAS]
Gene Ontology Molecular Function
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Perturbation of the mutated EGFR interactome identifies vulnerabilities and resistance mechanisms.
We hypothesized that elucidating the interactome of epidermal growth factor receptor (EGFR) forms that are mutated in lung cancer, via global analysis of protein-protein interactions, phosphorylation, and systematically perturbing the ensuing network nodes, should offer a new, more systems-level perspective of the molecular etiology. Here, we describe an EGFR interactome of 263 proteins and offer a 14-protein core network critical ... [more]
Throughput
- High Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| CDC37 RPS6KA6 | Co-fractionation Co-fractionation Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex. | High | 0.751 | BioGRID | 754462 |
Curated By
- BioGRID