ARRB1
Gene Ontology Biological Process
- G-protein coupled receptor internalization [IMP]
- Notch signaling pathway [TAS]
- blood coagulation [TAS]
- membrane organization [TAS]
- negative regulation of NF-kappaB transcription factor activity [IDA]
- negative regulation of interleukin-6 production [IDA]
- negative regulation of interleukin-8 production [IDA]
- negative regulation of protein ubiquitination [IDA]
- platelet activation [TAS]
- positive regulation of ERK1 and ERK2 cascade [IDA]
- positive regulation of GTPase activity [IMP]
- positive regulation of Rho protein signal transduction [IMP]
- positive regulation of histone H4 acetylation [IMP]
- positive regulation of histone acetylation [IMP]
- positive regulation of protein phosphorylation [IMP]
- positive regulation of receptor internalization [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IMP]
- post-Golgi vesicle-mediated transport [TAS]
- proteasome-mediated ubiquitin-dependent protein catabolic process [IMP]
- protein ubiquitination [IMP]
- stress fiber assembly [IMP]
- transcription from RNA polymerase II promoter [IMP]
Gene Ontology Molecular Function- GTPase activator activity [IMP]
- angiotensin receptor binding [IPI]
- enzyme inhibitor activity [TAS]
- histone acetyltransferase activity [IDA]
- insulin-like growth factor receptor binding [IPI]
- protein binding [IPI]
- transcription factor binding [IPI]
- transcription regulatory region DNA binding [IMP]
- ubiquitin protein ligase binding [IPI]
- GTPase activator activity [IMP]
- angiotensin receptor binding [IPI]
- enzyme inhibitor activity [TAS]
- histone acetyltransferase activity [IDA]
- insulin-like growth factor receptor binding [IPI]
- protein binding [IPI]
- transcription factor binding [IPI]
- transcription regulatory region DNA binding [IMP]
- ubiquitin protein ligase binding [IPI]
Gene Ontology Cellular Component
DRD4
Gene Ontology Biological Process
- activation of MAPK activity [IDA]
- adenylate cyclase-inhibiting dopamine receptor signaling pathway [IDA]
- adult locomotory behavior [ISS]
- arachidonic acid secretion [IDA]
- behavioral fear response [NAS]
- behavioral response to cocaine [ISS]
- behavioral response to ethanol [TAS]
- cellular calcium ion homeostasis [IC]
- dopamine metabolic process [IC]
- dopamine receptor signaling pathway [IDA]
- fear response [ISS]
- negative regulation of adenylate cyclase activity [IDA]
- negative regulation of cAMP biosynthetic process [IDA]
- negative regulation of protein secretion [IDA]
- negative regulation of voltage-gated calcium channel activity [IDA]
- positive regulation of dopamine uptake involved in synaptic transmission [IC]
- positive regulation of kinase activity [IDA]
- positive regulation of sodium:proton antiporter activity [IDA]
- regulation of circadian rhythm [ISS]
- regulation of dopamine metabolic process [ISS]
- regulation of inhibitory postsynaptic membrane potential [ISS]
- response to amphetamine [ISS]
- response to histamine [IDA]
- social behavior [NAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Characterization of the interaction between the dopamine D4 receptor, KLHL12 and β-arrestins.
Dopamine receptors are G protein-coupled receptors involved in regulation of cognition, learning, movement and endocrine signaling. The action of G protein-coupled receptors is highly regulated by multifunctional proteins, such as β-arrestins which can control receptor desensitization, ubiquitination and signaling. Previously, we have reported that β-arrestin 2 interacts with KLHL12, a BTB-Kelch protein which functions as an adaptor in a Cullin3-based ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID