BAIT

FBXL17

FBXO13, Fbl17, Fbx13
F-box and leucine-rich repeat protein 17
UPS Project
GO Process (0)
GO Function (0)
GO Component (0)
Homo sapiens
PREY

PJA2

Neurodap1, RNF131
praja ring finger 2, E3 ubiquitin protein ligase
Cell Cycle - Mitotic Spindle Assembly Project
UPS Project
Homo sapiens

Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

SCF (Fbxl17) ubiquitylation of Sufu regulates Hedgehog signaling and medulloblastoma development.

Raducu M, Fung E, Serres S, Infante P, Barberis A, Fischer R, Bristow C, Thezenas ML, Finta C, Christianson JC, Buffa FM, Kessler BM, Sibson NR, Di Marcotullio L, Toftgard R, D'Angiolella V

Skp1-Cul1-F-box protein (SCF) ubiquitin ligases direct cell survival decisions by controlling protein ubiquitylation and degradation. Sufu (Suppressor of fused) is a central regulator of Hh (Hedgehog) signaling and acts as a tumor suppressor by maintaining the Gli (Glioma-associated oncogene homolog) transcription factors inactive. Although Sufu has a pivotal role in Hh signaling, the players involved in controlling Sufu levels and ... [more]

EMBO J. Jul. 01, 2016; 35(13);1400-16 [Pubmed: 27234298]

Throughput

  • High Throughput

Additional Notes

  • Purification from HEK293T using Flag tagged Fbxl17

Curated By

  • BioGRID