BAIT
U2AF2
U2AF65
U2 small nuclear RNA auxiliary factor 2
GO Process (10)
GO Function (3)
GO Component (4)
Gene Ontology Biological Process
- RNA splicing [TAS]
- gene expression [TAS]
- mRNA 3'-end processing [TAS]
- mRNA export from nucleus [TAS]
- mRNA processing [TAS]
- mRNA splicing, via spliceosome [IC, TAS]
- negative regulation of mRNA splicing, via spliceosome [IDA]
- positive regulation of RNA splicing [IDA]
- termination of RNA polymerase II transcription [TAS]
- transcription from RNA polymerase II promoter [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
CALR
CRT, HEL-S-99n, RO, SSA, cC1qR
calreticulin
GO Process (33)
GO Function (15)
GO Component (17)
Gene Ontology Biological Process
- activation of signaling protein activity involved in unfolded protein response [TAS]
- antigen processing and presentation of exogenous peptide antigen via MHC class I [TAS]
- antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent [TAS]
- antigen processing and presentation of peptide antigen via MHC class I [TAS]
- cell cycle arrest [IGI]
- cellular calcium ion homeostasis [TAS]
- cellular protein metabolic process [TAS]
- cellular senescence [IGI]
- endoplasmic reticulum unfolded protein response [TAS]
- glucocorticoid receptor signaling pathway [TAS]
- negative regulation of intracellular steroid hormone receptor signaling pathway [IDA]
- negative regulation of neuron differentiation [IDA]
- negative regulation of retinoic acid receptor signaling pathway [IDA]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- negative regulation of transcription, DNA-templated [IDA]
- negative regulation of translation [ISS, TAS]
- peptide antigen assembly with MHC class I protein complex [ISS]
- positive regulation of DNA replication [IGI]
- positive regulation of cell cycle [IGI]
- positive regulation of cell proliferation [IGI]
- positive regulation of dendritic cell chemotaxis [IMP]
- positive regulation of phagocytosis [ISS]
- positive regulation of substrate adhesion-dependent cell spreading [IMP]
- post-translational protein modification [TAS]
- protein N-linked glycosylation via asparagine [TAS]
- protein export from nucleus [IDA]
- protein folding [TAS]
- protein localization to nucleus [IDA]
- protein maturation by protein folding [TAS]
- protein stabilization [ISS, TAS]
- regulation of apoptotic process [TAS]
- regulation of transcription, DNA-templated [TAS]
- sequestering of calcium ion [TAS]
Gene Ontology Molecular Function- DNA binding [NAS]
- androgen receptor binding [IDA]
- calcium ion binding [ISS, TAS]
- carbohydrate binding [TAS]
- chaperone binding [TAS]
- complement component C1q binding [TAS]
- glycoprotein binding [IPI]
- integrin binding [IPI]
- mRNA binding [IDA]
- poly(A) RNA binding [IDA]
- protein binding [IPI]
- protein binding involved in protein folding [TAS]
- ubiquitin protein ligase binding [IPI]
- unfolded protein binding [TAS]
- zinc ion binding [TAS]
- DNA binding [NAS]
- androgen receptor binding [IDA]
- calcium ion binding [ISS, TAS]
- carbohydrate binding [TAS]
- chaperone binding [TAS]
- complement component C1q binding [TAS]
- glycoprotein binding [IPI]
- integrin binding [IPI]
- mRNA binding [IDA]
- poly(A) RNA binding [IDA]
- protein binding [IPI]
- protein binding involved in protein folding [TAS]
- ubiquitin protein ligase binding [IPI]
- unfolded protein binding [TAS]
- zinc ion binding [TAS]
Gene Ontology Cellular Component
- MHC class I peptide loading complex [ISS]
- cell surface [TAS]
- cytoplasm [IDA]
- cytosol [IDA]
- endocytic vesicle lumen [TAS]
- endoplasmic reticulum [IDA, TAS]
- endoplasmic reticulum lumen [IDA, TAS]
- extracellular region [TAS]
- extracellular space [IDA]
- extracellular vesicular exosome [IDA]
- focal adhesion [IDA]
- integral component of lumenal side of endoplasmic reticulum membrane [TAS]
- intracellular [TAS]
- membrane [IDA]
- nucleus [IDA]
- perinuclear region of cytoplasm [IDA]
- polysome [ISS]
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
The Activation-Induced Assembly of an RNA/Protein Interactome Centered on the Splicing Factor U2AF2 Regulates Gene Expression in Human CD4 T Cells.
Activation of CD4 T cells is a reaction to challenges such as microbial pathogens, cancer and toxins that defines adaptive immune responses. The roles of T cell receptor crosslinking, intracellular signaling, and transcription factor activation are well described, but the importance of post-transcriptional regulation by RNA-binding proteins (RBPs) has not been considered in depth. We describe a new model expanding ... [more]
PLoS ONE Dec. 08, 2015; 10(12);e0144409 [Pubmed: 26641092]
Throughput
- Low Throughput
Curated By
- BioGRID