PRKD1
Gene Ontology Biological Process
- Golgi organization [IMP]
- Golgi vesicle transport [ISS]
- cell proliferation [TAS]
- cellular response to oxidative stress [IDA]
- cellular response to vascular endothelial growth factor stimulus [IGI, IMP]
- integrin-mediated signaling pathway [TAS]
- intracellular signal transduction [IMP]
- negative regulation of cell death [IMP]
- negative regulation of endocytosis [TAS]
- peptidyl-serine phosphorylation [IDA]
- positive regulation of CREB transcription factor activity [IGI]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IMP]
- positive regulation of NF-kappaB transcription factor activity [IMP]
- positive regulation of angiogenesis [IGI, IMP]
- positive regulation of blood vessel endothelial cell migration [IGI, IMP]
- positive regulation of endothelial cell chemotaxis [IMP]
- positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway [IGI, IMP]
- positive regulation of endothelial cell migration [IMP]
- positive regulation of endothelial cell proliferation [IGI]
- positive regulation of histone deacetylase activity [IGI]
- positive regulation of neuron projection development [IMP]
- positive regulation of osteoblast differentiation [ISS]
- positive regulation of peptidyl-serine phosphorylation [IGI]
- positive regulation of transcription from RNA polymerase II promoter [IMP]
- protein autophosphorylation [TAS]
- protein kinase D signaling [IGI]
- regulation of integrin-mediated signaling pathway [TAS]
- regulation of keratinocyte proliferation [ISS]
- signal transduction [TAS]
- small molecule metabolic process [TAS]
- sphingolipid biosynthetic process [TAS]
- sphingolipid metabolic process [TAS]
- vascular endothelial growth factor receptor signaling pathway [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
NOS1
Gene Ontology Biological Process
- arginine catabolic process [IC]
- blood coagulation [TAS]
- cellular response to growth factor stimulus [ISS]
- exogenous drug catabolic process [ISS]
- interaction with host [TAS]
- multicellular organismal response to stress [IMP]
- myoblast fusion [TAS]
- negative regulation of blood pressure [IBA]
- negative regulation of calcium ion transport [ISS]
- negative regulation of calcium ion transport into cytosol [TAS]
- negative regulation of hydrolase activity [ISS]
- negative regulation of potassium ion transport [ISS]
- negative regulation of serotonin uptake [ISS]
- neurotransmitter biosynthetic process [TAS]
- nitric oxide biosynthetic process [IBA, ISS]
- nitric oxide mediated signal transduction [IBA]
- peptidyl-cysteine S-nitrosylation [ISS]
- phagosome maturation [TAS]
- positive regulation of guanylate cyclase activity [IBA]
- positive regulation of histone acetylation [ISS]
- positive regulation of sodium ion transmembrane transport [ISS]
- positive regulation of the force of heart contraction [ISS]
- positive regulation of transcription from RNA polymerase II promoter [ISS]
- positive regulation of transcription, DNA-templated [ISS]
- positive regulation of vasodilation [IDA, IMP]
- regulation of cardiac muscle contraction [TAS]
- regulation of sodium ion transport [ISS]
- response to heat [IDA]
- response to hypoxia [IEP]
- striated muscle contraction [ISS]
Gene Ontology Molecular Function- FMN binding [ISS]
- NADP binding [ISS]
- NADPH-hemoprotein reductase activity [IBA]
- arginine binding [TAS]
- cadmium ion binding [ISS]
- flavin adenine dinucleotide binding [ISS]
- heme binding [ISS]
- ion channel binding [ISS]
- nitric-oxide synthase activity [IBA, ISS]
- oxidoreductase activity [IBA]
- protein binding [IPI]
- scaffold protein binding [ISS]
- sodium channel regulator activity [ISS]
- tetrahydrobiopterin binding [NAS]
- FMN binding [ISS]
- NADP binding [ISS]
- NADPH-hemoprotein reductase activity [IBA]
- arginine binding [TAS]
- cadmium ion binding [ISS]
- flavin adenine dinucleotide binding [ISS]
- heme binding [ISS]
- ion channel binding [ISS]
- nitric-oxide synthase activity [IBA, ISS]
- oxidoreductase activity [IBA]
- protein binding [IPI]
- scaffold protein binding [ISS]
- sodium channel regulator activity [ISS]
- tetrahydrobiopterin binding [NAS]
Gene Ontology Cellular Component
Biochemical Activity (Phosphorylation)
An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.
Publication
Protein kinase D interacts with neuronal nitric oxide synthase and phosphorylates the activatory residue serine 1412.
Neuronal Nitric Oxide Synthase (nNOS) is the biosynthetic enzyme responsible for nitric oxide (·NO) production in muscles and in the nervous system. This constitutive enzyme, unlike its endothelial and inducible counterparts, presents an N-terminal PDZ domain known to display a preference for PDZ-binding motifs bearing acidic residues at -2 position. In a previous work, we discovered that the C-terminal end ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| NOS1 PRKD1 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| PRKD1 NOS1 | Reconstituted Complex Reconstituted Complex An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator. | Low | - | BioGRID | - | |
| PRKD1 NOS1 | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | Low | - | BioGRID | - |
Curated By
- BioGRID