ALOX15
Gene Ontology Biological Process
- apoptotic cell clearance [ISS]
- arachidonic acid metabolic process [IDA, NAS, TAS]
- bone mineralization [ISS]
- cellular response to calcium ion [IDA]
- cellular response to interleukin-13 [IMP]
- hepoxilin biosynthetic process [ISS]
- inflammatory response [TAS]
- leukotriene metabolic process [TAS]
- lipoxin A4 biosynthetic process [ISS]
- lipoxygenase pathway [IDA, TAS]
- negative regulation of adaptive immune response [ISS]
- ossification [ISS]
- phosphatidylethanolamine biosynthetic process [ISS]
- positive regulation of ERK1 and ERK2 cascade [IMP]
- positive regulation of actin filament polymerization [ISS]
- positive regulation of cell-substrate adhesion [IDA]
- regulation of engulfment of apoptotic cell [ISS]
- regulation of peroxisome proliferator activated receptor signaling pathway [ISS]
- response to endoplasmic reticulum stress [ISS]
- small molecule metabolic process [TAS]
- wound healing [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
PRKDC
Gene Ontology Biological Process
- DNA repair [TAS]
- cellular protein modification process [TAS]
- cellular response to insulin stimulus [IMP]
- double-strand break repair [TAS]
- double-strand break repair via homologous recombination [IBA]
- double-strand break repair via nonhomologous end joining [TAS]
- innate immune response [TAS]
- negative regulation of protein phosphorylation [ISS]
- peptidyl-serine phosphorylation [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IMP]
- positive regulation of type I interferon production [TAS]
- regulation of circadian rhythm [ISS]
- signal transduction involved in mitotic G1 DNA damage checkpoint [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
15-lipoxygenase-1 activates tumor suppressor p53 independent of enzymatic activity.
15-LOX-1 and its metabolites are involved in colorectal cancer. Recently, we reported that 15-LOX-1 overexpression in HCT-116 human colorectal cancer cells inhibited cell growth by induction of p53 phosphorylation (4). To determine whether the 15-LOX-1 protein or its metabolites are responsible for phosphorylation of p53 in HCT-116 cells, we used HCT-116 cells that expressed a mutant 15-LOX-1. The mutant 15-LOX-1 ... [more]
Throughput
- Low Throughput
Additional Notes
- Figure 4
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| PRKDC ALOX15 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | 1526173 |
Curated By
- BioGRID