PLA2G6
Gene Ontology Biological Process
- Fc-gamma receptor signaling pathway involved in phagocytosis [TAS]
- cardiolipin acyl-chain remodeling [TAS]
- cardiolipin biosynthetic process [IMP]
- glycerophospholipid biosynthetic process [TAS]
- innate immune response [TAS]
- phosphatidylcholine acyl-chain remodeling [TAS]
- phosphatidylethanolamine acyl-chain remodeling [TAS]
- phospholipid metabolic process [TAS]
- small molecule metabolic process [TAS]
Gene Ontology Molecular Function
ARF1
Gene Ontology Biological Process
- Golgi to transport vesicle transport [ISO]
- actin filament organization [ISO]
- cellular copper ion homeostasis [ISO]
- dendritic spine organization [ISO]
- long term synaptic depression [ISO]
- positive regulation of ER to Golgi vesicle-mediated transport [ISO]
- positive regulation of calcium ion-dependent exocytosis [ISO]
- positive regulation of dendritic spine development [ISO]
- positive regulation of endocytosis [ISO]
- positive regulation of late endosome to lysosome transport [ISO]
- positive regulation of protein secretion [ISO]
- positive regulation of sodium ion transmembrane transport [ISO]
- protein transport [TAS]
- regulation of Arp2/3 complex-mediated actin nucleation [ISO]
- regulation of receptor internalization [ISO]
- synaptic vesicle budding [ISO]
- very-low-density lipoprotein particle assembly [ISO]
- vesicle-mediated transport [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
ADP ribosylation factors 1 and 4 and group VIA phospholipase Aâ‚‚ regulate morphology and intraorganellar traffic in the endoplasmic reticulum-Golgi intermediate compartment.
Organelle morphology of the endomembrane system is critical for optimal organelle function. ADP ribosylation factors (Arfs), a family of small GTPases, are required for maintaining the structure of the Golgi and endosomes. What determines the discontinuous nature of the endoplasmic reticulum (ER)-Golgi intermediate compartment (ERGIC) as tubulovesicular clusters is unknown. In search of morphological determinants for the ERGIC, we found ... [more]
Throughput
- Low Throughput
Additional Notes
- Figure 5
Curated By
- BioGRID