PEBP1
Gene Ontology Molecular Function
Gene Ontology Cellular Component
ALOX15
Gene Ontology Biological Process
- apoptotic cell clearance [ISS]
- arachidonic acid metabolic process [IDA, NAS, TAS]
- bone mineralization [ISS]
- cellular response to calcium ion [IDA]
- cellular response to interleukin-13 [IMP]
- hepoxilin biosynthetic process [ISS]
- inflammatory response [TAS]
- leukotriene metabolic process [TAS]
- lipoxin A4 biosynthetic process [ISS]
- lipoxygenase pathway [IDA, TAS]
- negative regulation of adaptive immune response [ISS]
- ossification [ISS]
- phosphatidylethanolamine biosynthetic process [ISS]
- positive regulation of ERK1 and ERK2 cascade [IMP]
- positive regulation of actin filament polymerization [ISS]
- positive regulation of cell-substrate adhesion [IDA]
- regulation of engulfment of apoptotic cell [ISS]
- regulation of peroxisome proliferator activated receptor signaling pathway [ISS]
- response to endoplasmic reticulum stress [ISS]
- small molecule metabolic process [TAS]
- wound healing [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
15-Lipoxygenase 1 interacts with phosphatidylethanolamine-binding protein to regulate MAPK signaling in human airway epithelial cells.
Epithelial 15-lipoxygenase 1 (15LO1) and activated ERK are increased in asthma despite modest elevations in IL-13. MAPK kinase (MEK)/ERK activation is regulated by interactions of Raf-1 with phosphatidylethanolamine-binding protein 1 (PEBP1). Epithelial 15LO1 generates intracellular 15-hydroxyeicosatetraenoic acid (15HETE) conjugated to phosphatidylethanolamine (PE) (15HETE-PE). We hypothesized that (i) 15LO1 and its product 15HETE-PE serve as signaling molecules interacting with PEBP1 to ... [more]
Throughput
- Low Throughput
Additional Notes
- Figure 3
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| ALOX15 PEBP1 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | 1526364 |
Curated By
- BioGRID