BAIT
RC3H1
RNF198, ROQUIN, RP5-1198E17.5
ring finger and CCCH-type domains 1
GO Process (11)
GO Function (3)
GO Component (2)
Gene Ontology Biological Process
- cytoplasmic mRNA processing body assembly [ISS]
- negative regulation of B cell proliferation [ISS]
- negative regulation of T-helper cell differentiation [ISS]
- negative regulation of activated T cell proliferation [ISS]
- negative regulation of germinal center formation [ISS]
- nuclear-transcribed mRNA catabolic process [ISS]
- posttranscriptional regulation of gene expression [ISS]
- protein ubiquitination [TAS]
- regulation of T cell receptor signaling pathway [ISS]
- regulation of germinal center formation [ISS]
- regulation of mRNA stability [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
CCT6A
CCT-zeta, CCT-zeta-1, CCT6, Cctz, HTR3, MoDP-2, TCP-1-zeta, TCP20, TCPZ, TTCP20
chaperonin containing TCP1, subunit 6A (zeta 1)
GO Process (3)
GO Function (2)
GO Component (4)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
RC3H1 post-transcriptionally regulates A20 mRNA and modulates the activity of the IKK/NF-κB pathway.
The RNA-binding protein RC3H1 (also known as ROQUIN) promotes TNFα mRNA decay via a 3'UTR constitutive decay element (CDE). Here we applied PAR-CLIP to human RC3H1 to identify ∼ 3,800 mRNA targets with >16,000 binding sites. A large number of sites are distinct from the consensus CDE and revealed a structure-sequence motif with U-rich sequences embedded in hairpins. RC3H1 binds ... [more]
Nat Commun Jul. 15, 2015; 6(0);7367 [Pubmed: 26170170]
Throughput
- High Throughput
Curated By
- BioGRID