PLIN5
Gene Ontology Biological Process
- lipid particle organization [IMP]
- lipid storage [IMP]
- mitochondrion localization [IMP]
- negative regulation of fatty acid beta-oxidation [IDA, IMP]
- negative regulation of lipase activity [IMP]
- negative regulation of lipid catabolic process [IDA]
- negative regulation of peroxisome proliferator activated receptor signaling pathway [IDA]
- negative regulation of reactive oxygen species metabolic process [IMP]
- negative regulation of triglyceride catabolic process [IDA]
- positive regulation of fatty acid beta-oxidation [IDA, ISO]
- positive regulation of lipase activity [ISO]
- positive regulation of lipid storage [ISO]
- positive regulation of sequestering of triglyceride [IDA, ISO]
- positive regulation of triglyceride biosynthetic process [IDA, IMP]
Gene Ontology Molecular Function
PNPLA2
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
FRET
An interaction is inferred when close proximity of interaction partners is detected by fluorescence resonance energy transfer between pairs of fluorophore-labeled molecules, such as occurs between CFP (donor) and YFP (acceptor) fusion proteins.
Publication
Interactions of perilipin-5 (Plin5) with adipose triglyceride lipase.
Members of the perilipin family of lipid droplet scaffold proteins are thought to play important roles in tissue-specific regulation of triglyceride metabolism, but the mechanisms involved are not fully understood. Present results indicate that adipose triglyceride lipase (Atgl) interacts with perilipin-5 (Plin5) but not perilipin-1 (Plin1). Protein interaction assays in live cells and in situ binding experiments showed that Atgl ... [more]
Throughput
- Low Throughput
Additional Notes
- Figure 2
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| PNPLA2 PLIN5 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| PNPLA2 PLIN5 | FRET FRET An interaction is inferred when close proximity of interaction partners is detected by fluorescence resonance energy transfer between pairs of fluorophore-labeled molecules, such as occurs between CFP (donor) and YFP (acceptor) fusion proteins. | Low | - | BioGRID | 903809 |
Curated By
- BioGRID