IL12B
Gene Ontology Biological Process
- T-helper 1 type immune response [TAS]
- T-helper cell differentiation [IDA]
- cell cycle arrest [IDA]
- cell migration [IDA]
- defense response to Gram-negative bacterium [IDA]
- interferon-gamma biosynthetic process [TAS]
- natural killer cell activation [IDA]
- negative regulation of interleukin-10 production [IMP]
- negative regulation of interleukin-17 production [IDA]
- negative regulation of smooth muscle cell proliferation [IDA]
- positive regulation of NF-kappaB import into nucleus [TAS]
- positive regulation of NK T cell activation [IC, IDA]
- positive regulation of NK T cell proliferation [IDA]
- positive regulation of T cell mediated cytotoxicity [ISS]
- positive regulation of T cell proliferation [IDA]
- positive regulation of T-helper 1 type immune response [IDA, ISS]
- positive regulation of T-helper 17 cell lineage commitment [ISS]
- positive regulation of T-helper 17 type immune response [ISS]
- positive regulation of activated T cell proliferation [IDA]
- positive regulation of activation of JAK2 kinase activity [IDA]
- positive regulation of cell adhesion [IDA]
- positive regulation of defense response to virus by host [IDA, ISS]
- positive regulation of granulocyte macrophage colony-stimulating factor production [IDA]
- positive regulation of inflammatory response [IC]
- positive regulation of interferon-gamma biosynthetic process [TAS]
- positive regulation of interferon-gamma production [IDA]
- positive regulation of interleukin-10 production [IDA, TAS]
- positive regulation of interleukin-12 production [IDA]
- positive regulation of interleukin-17 production [IDA]
- positive regulation of lymphocyte proliferation [IDA]
- positive regulation of memory T cell differentiation [ISS]
- positive regulation of mononuclear cell proliferation [IMP]
- positive regulation of natural killer cell activation [IC, IDA]
- positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target [IDA]
- positive regulation of natural killer cell proliferation [IDA]
- positive regulation of osteoclast differentiation [IDA]
- positive regulation of smooth muscle cell apoptotic process [IDA]
- positive regulation of tissue remodeling [IC]
- positive regulation of tumor necrosis factor production [IMP]
- positive regulation of tyrosine phosphorylation of Stat3 protein [IDA]
- positive regulation of tyrosine phosphorylation of Stat4 protein [IDA]
- positive regulation of tyrosine phosphorylation of Stat5 protein [IDA]
- regulation of cytokine biosynthetic process [TAS]
- regulation of tyrosine phosphorylation of Stat1 protein [IDA]
- response to UV-B [IDA]
- sexual reproduction [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
ERP44
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Celecoxib inhibits interleukin-12 alphabeta and beta2 folding and secretion by a novel COX2-independent mechanism involving chaperones of the endoplasmic reticulum.
Celecoxib (CE) is a nonsteroidal anti-inflammatory drug (NSAID) that is a specific inhibitor of cyclooxygenase 2 (COX2). It is indicated for a variety of chronic inflammatory conditions, including rheumatoid arthritis. Over the last few years, adverse cardiovascular effects and increased risk for heart attacks have been associated with this drug. In addition, evidence is emerging for COX2-independent molecular targets. CE ... [more]
Throughput
- Low Throughput
Additional Notes
- Figure 8
Curated By
- BioGRID