DUO1
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
GLC7
Gene Ontology Biological Process
- DNA damage checkpoint [IMP]
- DNA replication checkpoint [IGI, IMP]
- ascospore formation [IMP]
- cell budding [IMP]
- cellular ion homeostasis [IMP]
- chromosome segregation [IMP]
- dephosphorylation of RNA polymerase II C-terminal domain [IDA]
- glycogen metabolic process [IMP]
- histone dephosphorylation [IDA, IMP]
- meiotic nuclear division [IPI]
- mitotic spindle assembly checkpoint [IMP]
- positive regulation of protein dephosphorylation [IMP]
- protein dephosphorylation [IDA]
- protein localization to kinetochore [IMP]
- rRNA processing [IMP]
- regulation of carbohydrate metabolic process [IGI, IPI]
- regulation of cell cycle [IMP]
- regulation of cell shape during vegetative growth phase [IGI]
- regulation of mitotic cell cycle [IMP]
- replication fork processing [IMP]
- response to heat [IMP, IPI]
- termination of RNA polymerase II transcription, exosome-dependent [IPI]
- termination of RNA polymerase II transcription, poly(A)-coupled [IPI]
- transfer RNA gene-mediated silencing [IMP]
Gene Ontology Molecular Function
Dosage Lethality
A genetic interaction is inferred when over expression or increased dosage of one gene causes lethality in a strain that is mutated or deleted for another gene.
Publication
Functional cooperation of Dam1, Ipl1, and the inner centromere protein (INCENP)-related protein Sli15 during chromosome segregation.
We have shown previously that Ipl1 and Sli15 are required for chromosome segregation in Saccharomyces cerevisiae. Sli15 associates directly with the Ipl1 protein kinase and these two proteins colocalize to the mitotic spindle. We show here that Sli15 stimulates the in vitro, and likely in vivo, kinase activity of Ipl1, and Sli15 facilitates the association of Ipl1 with the mitotic ... [more]
Throughput
- Low Throughput
Ontology Terms
- phenotype: inviable (APO:0000112)
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| DUO1 GLC7 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -0.2465 | BioGRID | 1932559 |
Curated By
- BioGRID