SNF1
Gene Ontology Biological Process
- cell adhesion [IMP]
- cellular response to nitrogen starvation [IDA]
- fungal-type cell wall assembly [IMP]
- invasive growth in response to glucose limitation [IMP]
- negative regulation of translation [IGI, IMP]
- positive regulation of filamentous growth of a population of unicellular organisms in response to starvation [IMP]
- positive regulation of gluconeogenesis [IMP]
- protein phosphorylation [IDA]
- pseudohyphal growth [IMP]
- regulation of carbohydrate metabolic process [IGI, IPI]
- replicative cell aging [IGI, IMP]
- single-species surface biofilm formation [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
MIG3
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Dosage Lethality
A genetic interaction is inferred when over expression or increased dosage of one gene causes lethality in a strain that is mutated or deleted for another gene.
Publication
The protein kinase Snf1 is required for tolerance to the ribonucleotide reductase inhibitor hydroxyurea.
The Snf1/AMP-activated kinases are involved in a wide range of stress responses in eukaryotic cells. We discovered a novel role for the Snf1 kinase in the cellular response to genotoxic stress in yeast. snf1 mutants are hypersensitive to hydroxyurea (HU), methyl-methane sulfonate, and cadmium, but they are not sensitive to several other genotoxic agents. HU inhibits ribonucleotide reductase (RNR), and ... [more]
Throughput
- Low Throughput
Ontology Terms
- phenotype: resistance to chemicals (APO:0000087)
- phenotype: inviable (APO:0000112)
Additional Notes
- overexpression of Mig3 increases sensitivity to HU (CID 3657 CHEBI 44423) in an snf1 mutant background
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| SNF1 MIG3 | Biochemical Activity Biochemical Activity An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation. | Low | - | BioGRID | 151446 | |
| SNF1 MIG3 | Dosage Growth Defect Dosage Growth Defect A genetic interaction is inferred when over expression or increased dosage of one gene causes a growth defect in a strain that is mutated or deleted for another gene. | High | -0.252 | BioGRID | 909368 | |
| SNF1 MIG3 | Synthetic Rescue Synthetic Rescue A genetic interaction is inferred when mutations or deletions of one gene rescues the lethality or growth defect of a strain mutated or deleted for another gene. | Low | - | BioGRID | 159617 |
Curated By
- BioGRID