BAIT

MEC1

ESR1, RAD31, SAD3, protein kinase MEC1, L000000586, S000029404, S000007656, YBR136W
Genome integrity checkpoint protein and PI kinase superfamily member; Mec1p and Dun1p function in same pathway to regulate dNTP pools and telomere length; signal transducer required for cell cycle arrest and transcriptional responses to damaged or unreplicated DNA; facilitates replication fork progression and regulates P-body formation under replication stress; promotes interhomolog recombination by phosphorylating Hop1p; associates with shortened, dysfunctional telomeres
Kinome Project (Sc)
Saccharomyces cerevisiae (S288c)
PREY

RCK1

putative serine/threonine protein kinase RCK1, L000001592, YGL158W
Protein kinase involved in the response to oxidative stress; identified as suppressor of S. pombe cell cycle checkpoint mutations; RCK1 has a paralog, RCK2, that arose from the whole genome duplication
Kinome Project (Sc)
GO Process (2)
GO Function (2)
GO Component (0)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Saccharomyces cerevisiae (S288c)

Dosage Lethality

A genetic interaction is inferred when over expression or increased dosage of one gene causes lethality in a strain that is mutated or deleted for another gene.

Publication

The protein kinases Rck1 and Rck2 inhibit meiosis in budding yeast.

Ramne A, Bilsland-Marchesan E, Erickson S, Sunnerhagen P

The genes RCK1 and RCK2 of budding yeast were initially identified as suppressors of checkpoint mutations in fission yeast. Here, we show that homozygous diploid rck1/rck1 mutants in standard sporulation medium enter meiosis in about half the time required by wild-type cells. A similar, but weaker, effect is seen in rck2/rck2 mutants, whereas double homozygous rck1/rck1 rck2/rck2 mutants display a ... [more]

Mol. Gen. Genet. Mar. 01, 2000; 263(2);253-61 [Pubmed: 10778743]

Throughput

  • Low Throughput

Ontology Terms

  • phenotype: inviable (APO:0000112)

Curated By

  • BioGRID