BAIT

SHC1

L000001879, YER096W
Sporulation-specific activator of Chs3p (chitin synthase III); required for the synthesis of the chitosan layer of ascospores; transcriptionally induced at alkaline pH; SHC1 has a paralog, SKT5, that arose from the whole genome duplication
GO Process (2)
GO Function (1)
GO Component (1)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Saccharomyces cerevisiae (S288c)
PREY

SKT5

CAL2, CHS4, CSD4, L000001911, L000000332, YBL061C
Activator of Chs3p (chitin synthase III) during vegetative growth; recruits Chs3p to the bud neck via interaction with Bni4p; SKT5 has a paralog, SHC1, that arose from the whole genome duplication
GO Process (1)
GO Function (1)
GO Component (3)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Saccharomyces cerevisiae (S288c)

Dosage Rescue

A genetic interaction is inferred when over expression or increased dosage of one gene rescues the lethality or growth defect of a strain that is mutated or deleted for another gene.

Publication

Control of chitin synthesis through Shc1p, a functional homologue of Chs4p specifically induced during sporulation.

Sanz M, Trilla JA, Duran A, Roncero C

The Saccharomyces cerevisiae SHC1 gene encodes a protein with a high homology to Chs4p, a positive regulator of chitin synthase III (CSIII) during vegetative growth. SHC1 is not expressed during vegetative growth but is strongly induced during sporulation as a mid-late gene. shc1/shc1 mutants do not show any defect in the total rate of sporulation and meiosis occurs normally. However, ... [more]

Mol. Microbiol. Mar. 01, 2002; 43(5);1183-95 [Pubmed: 11918806]

Throughput

  • Low Throughput

Ontology Terms

  • phenotype: sporulation (APO:0000041)
  • phenotype: resistance to enzymatic treatment (APO:0000193)

Related interactions

InteractionExperimental Evidence CodeDatasetThroughputScoreCurated ByNotes
SKT5 SHC1
Negative Genetic
Negative Genetic

Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores.

High-0.1477BioGRID
2078354
SKT5 SHC1
Phenotypic Enhancement
Phenotypic Enhancement

A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.

Low-BioGRID
2389072

Curated By

  • BioGRID