STH1
Gene Ontology Biological Process
- ATP-dependent chromatin remodeling [IDA]
- G2/M transition of mitotic cell cycle [IMP]
- base-excision repair [IMP]
- chromatin remodeling at centromere [IMP]
- chromosome segregation [IGI]
- cytoskeleton organization [IGI, IMP]
- double-strand break repair [IMP]
- meiotic nuclear division [IMP]
- nucleosome disassembly [IDA]
- nucleosome positioning [IMP]
- regulation of transcription, DNA-templated [IMP]
- transcription elongation from RNA polymerase II promoter [IDA]
- transfer RNA gene-mediated silencing [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- RSC complex [IDA]
- nucleus [IDA]
PKC1
Gene Ontology Biological Process
- actin filament organization [IGI]
- cytoplasmic mRNA processing body assembly [IMP]
- intracellular signal transduction [IMP]
- peroxisome degradation [IMP]
- protein phosphorylation [IDA]
- regulation of fungal-type cell wall organization [IMP]
- regulation of nuclear-transcribed mRNA poly(A) tail shortening [IMP]
- signal transduction [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Dosage Rescue
A genetic interaction is inferred when over expression or increased dosage of one gene rescues the lethality or growth defect of a strain that is mutated or deleted for another gene.
Publication
Yeast RSC function is required for organization of the cellular cytoskeleton via an alternative PKC1 pathway.
RSC is a 15-protein ATP-dependent chromatin-remodeling complex related to Snf-Swi, the prototypical ATP-dependent nucleosome remodeler in budding yeast. Despite insight into the mechanism by which purified RSC remodels nucleosomes, little is known about the chromosomal targets or cellular pathways in which RSC acts. To better understand the cellular function of RSC, a screen was undertaken for gene dosage suppressors of ... [more]
Throughput
- Low Throughput
Ontology Terms
- phenotype: resistance to chemicals (APO:0000087)
- phenotype: heat sensitivity (APO:0000147)
- phenotype: vegetative growth (APO:0000106)
Additional Notes
- PKC1 overexpression rescues sensitivity to thiabendazole of sth1-3ts mutants
- PKC1 overexpression rescues temperature-sensitivity of sth1-3ts mutants
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| STH1 PKC1 | Dosage Rescue Dosage Rescue A genetic interaction is inferred when over expression or increased dosage of one gene rescues the lethality or growth defect of a strain that is mutated or deleted for another gene. | Low | - | BioGRID | 155008 | |
| STH1 PKC1 | Phenotypic Suppression Phenotypic Suppression A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene. | Low | - | BioGRID | 645319 | |
| PKC1 STH1 | Synthetic Lethality Synthetic Lethality A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition. | Low | - | BioGRID | 158475 |
Curated By
- BioGRID