RIM15
Gene Ontology Biological Process
Gene Ontology Molecular Function
MSN2
Gene Ontology Biological Process
- age-dependent response to oxidative stress involved in chronological cell aging [IGI]
- cellular response to blue light [IDA]
- cellular response to methylmercury [IGI, IMP]
- chromatin remodeling [IGI]
- positive regulation of transcription from RNA polymerase II promoter [IGI]
- positive regulation of transcription from RNA polymerase II promoter in response to a hypotonic environment [IGI]
- positive regulation of transcription from RNA polymerase II promoter in response to acidic pH [IGI, IMP]
- positive regulation of transcription from RNA polymerase II promoter in response to alkaline pH [IGI]
- positive regulation of transcription from RNA polymerase II promoter in response to amino acid starvation [IGI]
- positive regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance [IGI]
- positive regulation of transcription from RNA polymerase II promoter in response to cold [IGI]
- positive regulation of transcription from RNA polymerase II promoter in response to ethanol [IGI]
- positive regulation of transcription from RNA polymerase II promoter in response to freezing [IGI]
- positive regulation of transcription from RNA polymerase II promoter in response to glucose starvation [IGI]
- positive regulation of transcription from RNA polymerase II promoter in response to heat stress [IGI, IMP]
- positive regulation of transcription from RNA polymerase II promoter in response to hydrogen peroxide [IGI, IMP]
- positive regulation of transcription from RNA polymerase II promoter in response to hydrostatic pressure [IGI]
- positive regulation of transcription from RNA polymerase II promoter in response to increased salt [IGI]
- positive regulation of transcription from RNA polymerase II promoter in response to nitrosative stress [IGI]
- positive regulation of transcription from RNA polymerase II promoter in response to zinc ion starvation [IGI]
- regulation of replicative cell aging by regulation of transcription from RNA polymerase II promoter in response to caloric restriction [IGI]
- replicative cell aging [IGI]
Gene Ontology Molecular Function
Phenotypic Enhancement
A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.
Publication
Chronological aging-independent replicative life span regulation by Msn2/Msn4 and Sod2 in Saccharomyces cerevisiae.
Mutations in RAS2, CYR1, and SCH9 extend the chronological life span in Saccharomyces cerevisiae by activating stress-resistance transcription factors and mitochondrial superoxide dismutase (Sod2). Here we show that mutations in CYR1 and SCH9 also extend the replicative life span of individual yeast mother cells. However, the triple deletion of stress-resistance genes MSN2/MSN4 and RIM15, which causes a major decrease in ... [more]
Throughput
- Low Throughput
Ontology Terms
- phenotype: lifespan (APO:0000030)
Additional Notes
- in msn4 background
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| RIM15 MSN2 | Biochemical Activity Biochemical Activity An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation. | Low | - | BioGRID | 907754 | |
| MSN2 RIM15 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -3.1216 | BioGRID | 543265 | |
| MSN2 RIM15 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -0.1853 | BioGRID | 2161251 | |
| MSN2 RIM15 | Phenotypic Suppression Phenotypic Suppression A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene. | Low | - | BioGRID | 268347 |
Curated By
- BioGRID