SGV1
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
SPT4
Gene Ontology Biological Process
- 7-methylguanosine mRNA capping [IGI]
- chromatin organization [IMP]
- chromatin silencing [IMP]
- chromosome segregation [IMP]
- intracellular mRNA localization [IMP]
- mRNA splicing, via spliceosome [IMP]
- negative regulation of transcription elongation from RNA polymerase I promoter [IGI]
- positive regulation of transcription elongation from RNA polymerase I promoter [IMP]
- positive regulation of transcription elongation from RNA polymerase II promoter [IMP]
- regulation of rRNA processing [IMP]
- regulation of transcription, DNA-templated [IMP]
- regulation of transcription-coupled nucleotide-excision repair [IGI]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Synthetic Growth Defect
A genetic interaction is inferred when mutations in separate genes, each of which alone causes a minimal phenotype, result in a significant growth defect under a given condition when combined in the same cell.
Publication
Genetic interactions of Spt4-Spt5 and TFIIS with the RNA polymerase II CTD and CTD modifying enzymes in Saccharomyces cerevisiae.
Genetic and biochemical studies have identified many factors thought to be important for transcription elongation. We investigated relationships between three classes of these factors: (1) transcription elongation factors Spt4-Spt5, TFIIS, and Spt16; (2) the C-terminal heptapeptide repeat domain (CTD) of RNA polymerase II; and (3) protein kinases that phosphorylate the CTD and a phosphatase that dephosphorylates it. We observe that ... [more]
Throughput
- Low Throughput
Ontology Terms
- phenotype: vegetative growth (APO:0000106)
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
SGV1 SPT4 | Synthetic Lethality Synthetic Lethality A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition. | Low | - | BioGRID | 157688 |
Curated By
- BioGRID