CDC12
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
SWE1
Gene Ontology Biological Process
- G2 cell size control checkpoint [IEP, IMP]
- G2/M transition of mitotic cell cycle [IDA, IMP, ISS]
- cytokinesis after mitosis checkpoint [IDA, IEP, IMP]
- negative regulation of spindle pole body separation [IGI, IMP]
- protein phosphorylation [IDA]
- re-entry into mitotic cell cycle [IGI]
- regulation of cell size [IMP]
- regulation of cyclin-dependent protein serine/threonine kinase activity [IDA]
- regulation of meiosis [IEP, IGI, IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Synthetic Lethality
A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.
Publication
Nim1-related kinases coordinate cell cycle progression with the organization of the peripheral cytoskeleton in yeast.
The mechanisms that couple cell cycle progression with the organization of the peripheral cytoskeleton are poorly understood. In Saccharomyces cerevisiae, the Swe1 protein has been shown previously to phosphorylate and inactivate the cyclin-dependent kinase, Cdc28, thereby delaying the onset of mitosis. The nim1-related protein kinase, Hsl1, induces entry into mitosis by negatively regulating Swe1. We have found that Hsl1 physically ... [more]
Throughput
- Low Throughput
Ontology Terms
- phenotype: inviable (APO:0000112)
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
CDC12 SWE1 | Phenotypic Enhancement Phenotypic Enhancement A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene. | Low | - | BioGRID | 156136 | |
CDC12 SWE1 | Phenotypic Suppression Phenotypic Suppression A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene. | Low | - | BioGRID | 481362 | |
SWE1 CDC12 | Synthetic Lethality Synthetic Lethality A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition. | Low | - | BioGRID | 157747 |
Curated By
- BioGRID