MKK1
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
SDP1
Gene Ontology Biological Process
- MAPK cascade involved in cell wall organization or biogenesis [IGI]
- adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion [IBA]
- inactivation of MAPK activity involved in cell wall organization or biogenesis [IMP]
- regulation of pheromone-dependent signal transduction involved in conjugation with cellular fusion [IBA]
Gene Ontology Molecular Function
Synthetic Lethality
A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.
Publication
Regulation of the Saccharomyces cerevisiae Slt2 kinase pathway by the stress-inducible Sdp1 dual specificity phosphatase.
The Slt2/Mpk1 mitogen-activated protein kinase (MAPK) cell integrity pathway is involved in maintenance of cell shape and integrity during vegetative growth and mating in Saccharomyces cerevisiae. Slt2 is activated by dual phosphorylation of a threonine and tyrosine residue in response to several environmental stresses that perturb cell integrity. Negative regulation of Slt2 is achieved via dephosphorylation by two protein-tyrosine phosphatases, ... [more]
Throughput
- Low Throughput
Ontology Terms
- phenotype: inviable (APO:0000112)
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| MKK1 SDP1 | Dosage Rescue Dosage Rescue A genetic interaction is inferred when over expression or increased dosage of one gene rescues the lethality or growth defect of a strain that is mutated or deleted for another gene. | Low | - | BioGRID | 155311 |
Curated By
- BioGRID