SLT2
Gene Ontology Biological Process
- UFP-specific transcription factor mRNA processing involved in endoplasmic reticulum unfolded protein response [IMP]
- barrier septum assembly [IGI]
- endoplasmic reticulum unfolded protein response [IDA, IMP]
- fungal-type cell wall biogenesis [IGI]
- peroxisome degradation [IMP]
- protein phosphorylation [IDA, IMP]
- regulation of cell size [IMP]
- regulation of fungal-type cell wall organization [IGI, IMP]
- regulation of transcription factor import into nucleus [IMP]
- response to acidic pH [IMP]
- signal transduction [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
GLC7
Gene Ontology Biological Process
- DNA damage checkpoint [IMP]
- DNA replication checkpoint [IGI, IMP]
- ascospore formation [IMP]
- cell budding [IMP]
- cellular ion homeostasis [IMP]
- chromosome segregation [IMP]
- dephosphorylation of RNA polymerase II C-terminal domain [IDA]
- glycogen metabolic process [IMP]
- histone dephosphorylation [IDA, IMP]
- meiotic nuclear division [IPI]
- mitotic spindle assembly checkpoint [IMP]
- positive regulation of protein dephosphorylation [IMP]
- protein dephosphorylation [IDA]
- protein localization to kinetochore [IMP]
- rRNA processing [IMP]
- regulation of carbohydrate metabolic process [IGI, IPI]
- regulation of cell cycle [IMP]
- regulation of cell shape during vegetative growth phase [IGI]
- regulation of mitotic cell cycle [IMP]
- replication fork processing [IMP]
- response to heat [IMP, IPI]
- termination of RNA polymerase II transcription, exosome-dependent [IPI]
- termination of RNA polymerase II transcription, poly(A)-coupled [IPI]
- transfer RNA gene-mediated silencing [IMP]
Gene Ontology Molecular Function
Synthetic Lethality
A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.
Publication
Type 1 protein phosphatase is required for maintenance of cell wall integrity, morphogenesis and cell cycle progression in Saccharomyces cerevisiae.
GLC7 encodes the catalytic subunit of type 1 protein serine/threonine phosphatase (PP1) in the yeast Saccharomyces cerevisiae. Here we have characterized the temperature-sensitive glc7-10 allele, which displays aberrant bud morphology and an abnormal actin cytoskeleton at the restrictive temperature. At 37 degrees C glc7-10 strains accumulated a high proportion of budded cells with an unmigrated nucleus, duplicated spindle pole bodies, ... [more]
Throughput
- Low Throughput
Ontology Terms
- phenotype: resistance to chemicals (APO:0000087)
- phenotype: inviable (APO:0000112)
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| SLT2 GLC7 | Dosage Growth Defect Dosage Growth Defect A genetic interaction is inferred when over expression or increased dosage of one gene causes a growth defect in a strain that is mutated or deleted for another gene. | High | -0.403 | BioGRID | 909256 | |
| GLC7 SLT2 | Dosage Rescue Dosage Rescue A genetic interaction is inferred when over expression or increased dosage of one gene rescues the lethality or growth defect of a strain that is mutated or deleted for another gene. | Low | - | BioGRID | 154788 | |
| SLT2 GLC7 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -0.517 | BioGRID | 2047178 |
Curated By
- BioGRID