RGA1
Gene Ontology Biological Process
- actin filament organization [IMP]
- budding cell apical bud growth [IPI]
- budding cell isotropic bud growth [IPI]
- establishment of cell polarity [IMP]
- invasive growth in response to glucose limitation [IPI]
- pheromone-dependent signal transduction involved in conjugation with cellular fusion [IGI]
- pseudohyphal growth [IPI]
- septin ring organization [IGI]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
PBS2
Gene Ontology Biological Process
- MAPK import into nucleus involved in osmosensory signaling pathway [IMP]
- actin filament organization [IMP]
- activation of MAPK activity involved in osmosensory signaling pathway [IMP]
- cellular response to heat [IMP]
- hyperosmotic response [IMP]
- osmosensory signaling pathway [IMP]
- protein phosphorylation [IDA, IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Synthetic Lethality
A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.
Publication
Mutation of RGA1, which encodes a putative GTPase-activating protein for the polarity-establishment protein Cdc42p, activates the pheromone-response pathway in the yeast Saccharomyces cerevisiae.
We have selected yeast mutants that exhibit a constitutively active pheromone-response pathway in the absence of the beta subunit of the trimeric G protein. Genetic analysis of one such mutant revealed that it contained recessive mutations in two distinct genes, both of which contributed to the constitutive phenotype. One mutation identifies the RGA1 locus (Rho GTPase activating protein), which encodes ... [more]
Throughput
- Low Throughput
Ontology Terms
- phenotype: inviable (APO:0000112)
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
PBS2 RGA1 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -0.2372 | BioGRID | 390236 | |
RGA1 PBS2 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -0.2372 | BioGRID | 415894 | |
RGA1 PBS2 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -0.2453 | BioGRID | 2184303 | |
RGA1 PBS2 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -0.237 | BioGRID | 910371 | |
PBS2 RGA1 | Synthetic Lethality Synthetic Lethality A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition. | Low | - | BioGRID | 158447 |
Curated By
- BioGRID