BAIT
STE11
mitogen-activated protein kinase kinase kinase STE11, L000002118, YLR362W
Signal transducing MEK kinase; involved in pheromone response and pseudohyphal/invasive growth pathways where it phosphorylates Ste7p, and the high osmolarity response pathway, via phosphorylation of Pbs2p; regulated by Ste20p and Ste50p; protein abundance increases in response to DNA replication stress
GO Process (11)
GO Function (3)
GO Component (1)
Gene Ontology Biological Process
- MAPK cascade involved in cell wall organization or biogenesis [IGI]
- MAPK cascade involved in osmosensory signaling pathway [IGI, IMP]
- activation of MAPKK activity [IDA, IMP]
- cellular response to heat [IMP]
- invasive growth in response to glucose limitation [IMP]
- osmosensory signaling pathway via Sho1 osmosensor [IGI]
- pheromone-dependent signal transduction involved in conjugation with cellular fusion [IMP]
- protein phosphorylation [IDA, IMP]
- pseudohyphal growth [IMP]
- regulation of transposition, RNA-mediated [IMP]
- signal transduction involved in filamentous growth [IMP]
Gene Ontology Molecular Function
Saccharomyces cerevisiae (S288c)
PREY
DOC1
APC10, anaphase promoting complex subunit DOC1, L000004350, YGL240W
Processivity factor; required for the ubiquitination activity of the anaphase promoting complex (APC), mediates the activity of the APC by contributing to substrate recognition; involved in cyclin proteolysis; contains a conserved DOC1 homology domain
GO Process (4)
GO Function (2)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Saccharomyces cerevisiae (S288c)
Synthetic Lethality
A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.
Publication
Synergistic inhibition of APC/C by glucose and activated Ras proteins can be mediated by each of the Tpk1-3 proteins in Saccharomyces cerevisiae.
Proteolysis triggered by the anaphase-promoting complex/cyclosome (APC/C) is essential for the progression through mitosis. APC/C is a highly conserved ubiquitin ligase whose activity is regulated during the cell cycle by various factors, including spindle checkpoint components and protein kinases. The cAMP-dependent protein kinase (PKA) was identified as negative regulator of APC/C in yeast and mammalian cells. In the yeast Saccharomyces ... [more]
Microbiology (Reading, Engl.) May. 01, 2003; 149(0);1205-16 [Pubmed: 12724382]
Throughput
- Low Throughput
Ontology Terms
- phenotype: inviable (APO:0000112)
Curated By
- BioGRID