SST2
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
KSS1
Gene Ontology Biological Process
- invasive growth in response to glucose limitation [IMP]
- negative regulation of sequence-specific DNA binding transcription factor activity [IMP]
- pheromone-dependent signal transduction involved in conjugation with cellular fusion [IEP, IMP]
- protein phosphorylation [IDA]
- signal transduction involved in filamentous growth [IGI, IMP]
Gene Ontology Molecular Function
Phenotypic Suppression
A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.
Publication
A putative protein kinase overcomes pheromone-induced arrest of cell cycling in S. cerevisiae.
MATa cells carrying an sst2 mutation are unable to recover from the G1-specific cell cycle arrest induced by the mating pheromone alpha factor. The KSS1 gene, when overexpressed, suppresses this adaptation defect. KSS1 overexpression also suppresses the recovery defect manifested by cells expressing an alpha factor receptor lacking its 136 amino acid cytoplasmic tail. Because SST2 product and the receptor ... [more]
Throughput
- Low Throughput
Ontology Terms
- phenotype: cell cycle progression (APO:0000253)
Additional Notes
- overexpression of KSS1 represses alpha factor induced cell cycle arrest seen in SST2 mutants
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| KSS1 SST2 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -0.1765 | BioGRID | 382013 | |
| SST2 KSS1 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -0.1765 | BioGRID | 401878 | |
| KSS1 SST2 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -0.176 | BioGRID | 911031 | |
| SST2 KSS1 | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | Low | - | BioGRID | - |
Curated By
- BioGRID